BRD-K90382497_GW-843682X_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K90382497_GW-843682X_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALCAM activated leukocyte cell adhesion molecule
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARG2 arginase 2
C5AR1 complement component 5a receptor 1
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CDC20 cell division cycle 20
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLEC2B C-type lectin domain family 2, member B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEGS1 delta(4)-desaturase, sphingolipid 1
EHF ets homologous factor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
HOPX HOP homeobox
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCTD12 potassium channel tetramerization domain containing 12
MCL1 myeloid cell leukemia 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MYOF myoferlin
NPY neuropeptide Y
PALLD palladin, cytoskeletal associated protein
PDLIM5 PDZ and LIM domain 5
POSTN periostin, osteoblast specific factor
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS4 regulator of G-protein signaling 4
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STX3 syntaxin 3
THBS1 thrombospondin 1
TJP2 tight junction protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBB6 tubulin, beta 6 class V
TUFT1 tuftelin 1
VCAN versican
VSIG4 V-set and immunoglobulin domain containing 4
WSB2 WD repeat and SOCS box containing 2

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APOM apolipoprotein M
AUTS2 autism susceptibility candidate 2
CCL20 chemokine (C-C motif) ligand 20
CDK1 cyclin-dependent kinase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEMIP cell migration inducing protein, hyaluronan binding
COL15A1 collagen, type XV, alpha 1
COL2A1 collagen, type II, alpha 1
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
DHRS2 dehydrogenase/reductase (SDR family) member 2
EPS8 epidermal growth factor receptor pathway substrate 8
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPC3 glypican 3
GSTA1 glutathione S-transferase alpha 1
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HBB hemoglobin, beta
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
JADE2 jade family PHD finger 2
METTL7A methyltransferase like 7A
MYLK myosin light chain kinase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAH phenylalanine hydroxylase
PDZK1 PDZ domain containing 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PXMP2 peroxisomal membrane protein 2, 22kDa
RNASE4 ribonuclease, RNase A family, 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TCF4 transcription factor 4
TMPRSS11E transmembrane protease, serine 11E
TNC tenascin C
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNS1 tensin 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
XIST X inactive specific transcript (non-protein coding)