BRD-K90382497_GW-843682X_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K90382497_GW-843682X_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA10 annexin A10
ATF3 activating transcription factor 3
ATP11B ATPase, class VI, type 11B
CA2 carbonic anhydrase II
CCDC68 coiled-coil domain containing 68
CD14 CD14 molecule
CD163 CD163 molecule
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLIC1 chloride intracellular channel 1
CP ceruloplasmin (ferroxidase)
CRABP1 cellular retinoic acid binding protein 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CYB561 cytochrome b561
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FCGBP Fc fragment of IgG binding protein
FLOT1 flotillin 1
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
LY75 lymphocyte antigen 75
MUC2 mucin 2, oligomeric mucus/gel-forming
NES nestin
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
OARD1 O-acyl-ADP-ribose deacylase 1
PARP8 poly (ADP-ribose) polymerase family, member 8
PCDH17 protocadherin 17
PECAM1 platelet/endothelial cell adhesion molecule 1
PLK2 polo-like kinase 2
PLVAP plasmalemma vesicle associated protein
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPATS2L spermatogenesis associated, serine-rich 2-like
STX1A syntaxin 1A (brain)
TPPP3 tubulin polymerization-promoting protein family member 3
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
CALB1 calbindin 1, 28kDa
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFLAR CASP8 and FADD-like apoptosis regulator
CH25H cholesterol 25-hydroxylase
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
EDN1 endothelin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FLRT2 fibronectin leucine rich transmembrane protein 2
GREM1 gremlin 1, DAN family BMP antagonist
HADH hydroxyacyl-CoA dehydrogenase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHD immunoglobulin heavy constant delta
IGLL1 immunoglobulin lambda-like polypeptide 1
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMCD1 LIM and cysteine-rich domains 1
LUM lumican
MAGED1 melanoma antigen family D1
MAT2A methionine adenosyltransferase II, alpha
MCM6 minichromosome maintenance complex component 6
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAIP1 poly(A) binding protein interacting protein 1
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDZRN3 PDZ domain containing ring finger 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPT8 septin 8
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGM2 transglutaminase 2
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNS1 tensin 1
TSPYL5 TSPY-like 5
TXNDC9 thioredoxin domain containing 9
VCAM1 vascular cell adhesion molecule 1
VDAC1 voltage-dependent anion channel 1
ZBED1 zinc finger, BED-type containing 1