BRD-K90382497_GW-843682X_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K90382497_GW-843682X_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AMDHD2 amidohydrolase domain containing 2
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BHLHE41 basic helix-loop-helix family, member e41
CA2 carbonic anhydrase II
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC2B C-type lectin domain family 2, member B
COL6A2 collagen, type VI, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
GAL galanin/GMAP prepropeptide
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KAZN kazrin, periplakin interacting protein
KCNK1 potassium channel, two pore domain subfamily K, member 1
LCN2 lipocalin 2
MECOM MDS1 and EVI1 complex locus
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
NELL2 NEL-like 2 (chicken)
OSBPL3 oxysterol binding protein-like 3
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RTCA RNA 3'-terminal phosphate cyclase
S100P S100 calcium binding protein P
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SNX10 sorting nexin 10
SPON1 spondin 1, extracellular matrix protein
STK10 serine/threonine kinase 10
STX1A syntaxin 1A (brain)
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AHNAK AHNAK nucleoprotein
AK4 adenylate kinase 4
ALB albumin
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CCNF cyclin F
CD9 CD9 molecule
CDCA4 cell division cycle associated 4
CREB1 cAMP responsive element binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DMD dystrophin
DPT dermatopontin
DPYSL3 dihydropyrimidinase-like 3
EDN1 endothelin 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSTA1 glutathione S-transferase alpha 1
H2AFX H2A histone family, member X
HILPDA hypoxia inducible lipid droplet-associated
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL6 interleukin 6
INSIG1 insulin induced gene 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LMCD1 LIM and cysteine-rich domains 1
LMNA lamin A/C
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGRN neugrin, neurite outgrowth associated
NREP neuronal regeneration related protein
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PEG10 paternally expressed 10
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A10 S100 calcium binding protein A10
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SQLE squalene epoxidase
SRSF6 serine/arginine-rich splicing factor 6
STATH statherin
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THAP11 THAP domain containing 11
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM14A transmembrane protein 14A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
TNS3 tensin 3
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
WFS1 Wolfram syndrome 1 (wolframin)
ZBTB38 zinc finger and BTB domain containing 38