BRD-K90382497_GW-843682X_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K90382497_GW-843682X_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ANXA3 annexin A3
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AUTS2 autism susceptibility candidate 2
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CD81 CD81 molecule
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DSP desmoplakin
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
EREG epiregulin
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GAS6 growth arrest-specific 6
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
JADE2 jade family PHD finger 2
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MT1E metallothionein 1E
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MUC1 mucin 1, cell surface associated
OPTN optineurin
PLAGL1 pleiomorphic adenoma gene-like 1
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PTHLH parathyroid hormone-like hormone
PXDN peroxidasin
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100A2 S100 calcium binding protein A2
SATB1 SATB homeobox 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SIRT3 sirtuin 3
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOX thymocyte selection-associated high mobility group box
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
ANXA4 annexin A4
ASCL1 achaete-scute family bHLH transcription factor 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
C8ORF4 chromosome 8 open reading frame 4
CAST calpastatin
CBR3 carbonyl reductase 3
CDK1 cyclin-dependent kinase 1
CES1 carboxylesterase 1
CPVL carboxypeptidase, vitellogenic-like
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
E2F2 E2F transcription factor 2
FABP4 fatty acid binding protein 4, adipocyte
FGL1 fibrinogen-like 1
FN1 fibronectin 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX2 glutathione peroxidase 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
LXN latexin
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MARCKSL1 MARCKS-like 1
MGST2 microsomal glutathione S-transferase 2
MORC4 MORC family CW-type zinc finger 4
MYH11 myosin, heavy chain 11, smooth muscle
NDRG2 NDRG family member 2
PCYOX1L prenylcysteine oxidase 1 like
PDZK1 PDZ domain containing 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PLN phospholamban
RAP1GAP RAP1 GTPase activating protein
RNASE4 ribonuclease, RNase A family, 4
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THAP11 THAP domain containing 11
TJP2 tight junction protein 2
TOX3 TOX high mobility group box family member 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon