BRD-K90382497_GW-843682X_A375_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K90382497_GW-843682X_A375_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AIM1 absent in melanoma 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C7 complement component 7
CA2 carbonic anhydrase II
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
F3 coagulation factor III (thromboplastin, tissue factor)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HP haptoglobin
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
IRS2 insulin receptor substrate 2
LHFP lipoma HMGIC fusion partner
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
NFE2 nuclear factor, erythroid 2
NPY1R neuropeptide Y receptor Y1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
OSBPL3 oxysterol binding protein-like 3
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PTX3 pentraxin 3, long
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RPP38 ribonuclease P/MRP 38kDa subunit
SESN1 sestrin 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLPI secretory leukocyte peptidase inhibitor
TFRC transferrin receptor
TIGAR TP53 induced glycolysis regulatory phosphatase
WT1 Wilms tumor 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADGRE5 adhesion G protein-coupled receptor E5
AGA aspartylglucosaminidase
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
AQP3 aquaporin 3 (Gill blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATXN1 ataxin 1
BTBD3 BTB (POZ) domain containing 3
CCNF cyclin F
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDK1 cyclin-dependent kinase 1
CKAP4 cytoskeleton-associated protein 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRIP2 cysteine-rich protein 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP7 fatty acid binding protein 7, brain
FAM3C family with sequence similarity 3, member C
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR3 fibroblast growth factor receptor 3
FUCA1 fucosidase, alpha-L- 1, tissue
GSN gelsolin
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
IVL involucrin
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM5B lysine (K)-specific demethylase 5B
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LYPLA1 lysophospholipase I
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
NAV2 neuron navigator 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PERP PERP, TP53 apoptosis effector
PGM1 phosphoglucomutase 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
QPCT glutaminyl-peptide cyclotransferase
RHOBTB1 Rho-related BTB domain containing 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A11 S100 calcium binding protein A11
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SRPX sushi-repeat containing protein, X-linked
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB4B tubulin, beta 4B class IVb
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
WWTR1 WW domain containing transcription regulator 1