BRD-K90382497_GW 843682X_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K90382497_GW 843682X_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF4 activating transcription factor 4
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CHEK2 checkpoint kinase 2
CHI3L2 chitinase 3-like 2
CRISP3 cysteine-rich secretory protein 3
CTSC cathepsin C
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ELF5 E74-like factor 5 (ets domain transcription factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GTSE1 G-2 and S-phase expressed 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IGFBP4 insulin-like growth factor binding protein 4
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
MARCKS myristoylated alanine-rich protein kinase C substrate
MKI67 marker of proliferation Ki-67
NEK2 NIMA-related kinase 2
NGRN neugrin, neurite outgrowth associated
NUSAP1 nucleolar and spindle associated protein 1
PGC progastricsin (pepsinogen C)
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
RAB15 RAB15, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SATB2 SATB homeobox 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
BCAM basal cell adhesion molecule (Lutheran blood group)
CALB1 calbindin 1, 28kDa
CALML3 calmodulin-like 3
CFI complement factor I
CORO1A coronin, actin binding protein, 1A
CTBP2 C-terminal binding protein 2
EFNA1 ephrin-A1
EXT1 exostosin glycosyltransferase 1
F12 coagulation factor XII (Hageman factor)
FAM134B family with sequence similarity 134, member B
FHL1 four and a half LIM domains 1
GSTT1 glutathione S-transferase theta 1
HES1 hes family bHLH transcription factor 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM3 interferon induced transmembrane protein 3
IL2RG interleukin 2 receptor, gamma
INHBA inhibin, beta A
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MCM3 minichromosome maintenance complex component 3
MMP2 matrix metallopeptidase 2
MSLN mesothelin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NREP neuronal regeneration related protein
PCP4 Purkinje cell protein 4
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
POSTN periostin, osteoblast specific factor
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF144A ring finger protein 144A
SDC1 syndecan 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP1 TIMP metallopeptidase inhibitor 1
WLS wntless Wnt ligand secretion mediator