BRD-K90382497_GW 843682X_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K90382497_GW 843682X_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY9 adenylate cyclase 9
AURKA aurora kinase A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIC2 hypermethylated in cancer 2
HSPA2 heat shock 70kDa protein 2
LRRC59 leucine rich repeat containing 59
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MEIS2 Meis homeobox 2
MFSD12 major facilitator superfamily domain containing 12
MT1G metallothionein 1G
NLRP2 NLR family, pyrin domain containing 2
NPTX2 neuronal pentraxin II
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRPF3 pre-mRNA processing factor 3
RREB1 ras responsive element binding protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STC2 stanniocalcin 2
UFM1 ubiquitin-fold modifier 1

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANO1 anoctamin 1, calcium activated chloride channel
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C1ORF115 chromosome 1 open reading frame 115
CCDC85B coiled-coil domain containing 85B
CCNE2 cyclin E2
CD302 CD302 molecule
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CYB5A cytochrome b5 type A (microsomal)
DPP4 dipeptidyl-peptidase 4
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ETV1 ets variant 1
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
HMGA2 high mobility group AT-hook 2
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
MANSC1 MANSC domain containing 1
MCM2 minichromosome maintenance complex component 2
MCM7 minichromosome maintenance complex component 7
MMP1 matrix metallopeptidase 1
OPHN1 oligophrenin 1
PBX1 pre-B-cell leukemia homeobox 1
RELN reelin
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS5 regulator of G-protein signaling 5
RNASE4 ribonuclease, RNase A family, 4
SCGB2A2 secretoglobin, family 2A, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SEPP1 selenoprotein P, plasma, 1
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM45A transmembrane protein 45A
TOP2A topoisomerase (DNA) II alpha 170kDa
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)