BRD-K90382497_GW 843682X_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K90382497_GW 843682X_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
C1ORF56 chromosome 1 open reading frame 56
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DUSP6 dual specificity phosphatase 6
EVI2A ecotropic viral integration site 2A
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IRF8 interferon regulatory factor 8
ITGA6 integrin, alpha 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAPTM5 lysosomal protein transmembrane 5
LST1 leukocyte specific transcript 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MX1 MX dynamin-like GTPase 1
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL3 oxysterol binding protein-like 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCQ protein kinase C, theta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
STX3 syntaxin 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
XPOT exportin, tRNA
ZNF652 zinc finger protein 652
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ALDOA aldolase A, fructose-bisphosphate
APOD apolipoprotein D
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEFB1 defensin, beta 1
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
EGR2 early growth response 2
EGR3 early growth response 3
EHD3 EH-domain containing 3
EMP2 epithelial membrane protein 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLS glutaminase
GPI glucose-6-phosphate isomerase
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA2 heat shock 70kDa protein 2
INSIG1 insulin induced gene 1
LIG1 ligase I, DNA, ATP-dependent
LMCD1 LIM and cysteine-rich domains 1
MAP1B microtubule-associated protein 1B
MATN2 matrilin 2
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSH6 mutS homolog 6
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
MYLK myosin light chain kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDZK1 PDZ domain containing 1
PGM1 phosphoglucomutase 1
RNASE4 ribonuclease, RNase A family, 4
SDC2 syndecan 2
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SQLE squalene epoxidase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM45A transmembrane protein 45A
TNC tenascin C
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
WEE1 WEE1 G2 checkpoint kinase
WFS1 Wolfram syndrome 1 (wolframin)