BRD-K89329876_-666_MCF7_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-K89329876_-666_MCF7_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CDA cytidine deaminase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
FOSL1 FOS-like antigen 1
GLRX glutaredoxin (thioltransferase)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMG20B high mobility group 20B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER5 immediate early response 5
MALL mal, T-cell differentiation protein-like
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLPH melanophilin
MTSS1 metastasis suppressor 1
PDLIM1 PDZ and LIM domain 1
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
S100A10 S100 calcium binding protein A10
SESN1 sestrin 1
ST5 suppression of tumorigenicity 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TPSAB1 tryptase alpha/beta 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
C1ORF54 chromosome 1 open reading frame 54
CCNE2 cyclin E2
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CENPN centromere protein N
CKS1B CDC28 protein kinase regulatory subunit 1B
CXCL12 chemokine (C-X-C motif) ligand 12
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
FANCI Fanconi anemia, complementation group I
FKBP5 FK506 binding protein 5
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAT1 histone acetyltransferase 1
IL1R1 interleukin 1 receptor, type I
KIF11 kinesin family member 11
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYH10 myosin, heavy chain 10, non-muscle
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NPY neuropeptide Y
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RRM2 ribonucleotide reductase M2
SMC2 structural maintenance of chromosomes 2
SPC25 SPC25, NDC80 kinetochore complex component
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C