BRD-K89329876_-666_A375_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K89329876_-666_A375_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AMOTL2 angiomotin like 2
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
CA2 carbonic anhydrase II
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EXT1 exostosin glycosyltransferase 1
FZD6 frizzled class receptor 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GJA1 gap junction protein, alpha 1, 43kDa
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
IER5 immediate early response 5
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
LIMCH1 LIM and calponin homology domains 1
LOC100505650 uncharacterized LOC100505650
MEIS2 Meis homeobox 2
NVL nuclear VCP-like
P3H2 prolyl 3-hydroxylase 2
PBX3 pre-B-cell leukemia homeobox 3
PDE8B phosphodiesterase 8B
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PXDN peroxidasin
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGCC regulator of cell cycle
SESN1 sestrin 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM22 tripartite motif containing 22
ZMAT3 zinc finger, matrin-type 3
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
C8ORF4 chromosome 8 open reading frame 4
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDC25B cell division cycle 25B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
CST3 cystatin C
CTSC cathepsin C
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
F13A1 coagulation factor XIII, A1 polypeptide
GLUL glutamate-ammonia ligase
GMDS GDP-mannose 4,6-dehydratase
NPY1R neuropeptide Y receptor Y1
PCSK5 proprotein convertase subtilisin/kexin type 5
PLTP phospholipid transfer protein
PRSS3 protease, serine, 3
RNASE4 ribonuclease, RNase A family, 4
SACS sacsin molecular chaperone
SEPP1 selenoprotein P, plasma, 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa