BRD-K89209981_(4-(hydroxydiphenylmethyl)-1H-1,2,3-triazol-1-yl)(4-(hydroxydiphenylmethyl)piperidin-1-yl)methanone_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K89209981_(4-(hydroxydiphenylmethyl)-1H-1,2,3-triazol-1-yl)(4-(hydroxydiphenylmethyl)piperidin-1-yl)methanone_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
C14ORF132 chromosome 14 open reading frame 132
CASP2 caspase 2, apoptosis-related cysteine peptidase
CECR1 cat eye syndrome chromosome region, candidate 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FTH1 ferritin, heavy polypeptide 1
HLA-B major histocompatibility complex, class I, B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
KLK11 kallikrein-related peptidase 11
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTBP3 latent transforming growth factor beta binding protein 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MDK midkine (neurite growth-promoting factor 2)
MSMO1 methylsterol monooxygenase 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NES nestin
NQO1 NAD(P)H dehydrogenase, quinone 1
PODXL podocalyxin-like
RAMP1 receptor (G protein-coupled) activity modifying protein 1
REG1A regenerating islet-derived 1 alpha
RGS2 regulator of G-protein signaling 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
TFF1 trefoil factor 1
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
C1ORF116 chromosome 1 open reading frame 116
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLCA4 chloride channel accessory 4
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DUSP5 dual specificity phosphatase 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAIM Fas apoptotic inhibitory molecule
FLRT3 fibronectin leucine rich transmembrane protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
NNMT nicotinamide N-methyltransferase
PDLIM3 PDZ and LIM domain 3
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TSPAN13 tetraspanin 13
TUBB6 tubulin, beta 6 class V
TUSC3 tumor suppressor candidate 3
ZNF586 zinc finger protein 586