BRD-K89209981_(4-(hydroxydiphenylmethyl)-1H-1,2,3-triazol-1-yl)(4-(hydroxydiphenylmethyl)piperidin-1-yl)methanone_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K89209981_(4-(hydroxydiphenylmethyl)-1H-1,2,3-triazol-1-yl)(4-(hydroxydiphenylmethyl)piperidin-1-yl)methanone_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADM adrenomedullin
ALB albumin
AMPH amphiphysin
ANGPT2 angiopoietin 2
ARG2 arginase 2
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD200 CD200 molecule
CD52 CD52 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CERS6 ceramide synthase 6
CLEC5A C-type lectin domain family 5, member A
CNOT4 CCR4-NOT transcription complex, subunit 4
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
DCHS1 dachsous cadherin-related 1
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
ELMO3 engulfment and cell motility 3
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EXT1 exostosin glycosyltransferase 1
F11R F11 receptor
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FMOD fibromodulin
FN1 fibronectin 1
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GSDMB gasdermin B
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IPO13 importin 13
IRF6 interferon regulatory factor 6
ITM2A integral membrane protein 2A
JAG1 jagged 1
KCTD14 potassium channel tetramerization domain containing 14
KIAA0226L KIAA0226-like
LAPTM5 lysosomal protein transmembrane 5
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
MAOA monoamine oxidase A
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MT1G metallothionein 1G
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
NCAM1 neural cell adhesion molecule 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PPAP2B phosphatidic acid phosphatase type 2B
PYCR1 pyrroline-5-carboxylate reductase 1
RAB25 RAB25, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP4 secreted frizzled-related protein 4
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SMAD1 SMAD family member 1
SOX9 SRY (sex determining region Y)-box 9
TF transferrin
THY1 Thy-1 cell surface antigen
TMEM30B transmembrane protein 30B
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WNT5B wingless-type MMTV integration site family, member 5B
WSB1 WD repeat and SOCS box containing 1
ZHX2 zinc fingers and homeoboxes 2
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACE2 angiotensin I converting enzyme 2
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
AMACR alpha-methylacyl-CoA racemase
AQP3 aquaporin 3 (Gill blood group)
ASB9 ankyrin repeat and SOCS box containing 9
BASP1 brain abundant, membrane attached signal protein 1
BLMH bleomycin hydrolase
BST2 bone marrow stromal cell antigen 2
CBX3 chromobox homolog 3
CCNB2 cyclin B2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CENPU centromere protein U
CLIC4 chloride intracellular channel 4
CPVL carboxypeptidase, vitellogenic-like
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECI2 enoyl-CoA delta isomerase 2
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP3 epithelial membrane protein 3
ETV1 ets variant 1
F2R coagulation factor II (thrombin) receptor
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
FXYD2 FXYD domain containing ion transport regulator 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GGT1 gamma-glutamyltransferase 1
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
HEBP1 heme binding protein 1
HLTF helicase-like transcription factor
IGFBP7 insulin-like growth factor binding protein 7
IL13RA2 interleukin 13 receptor, alpha 2
IL18 interleukin 18
IQGAP2 IQ motif containing GTPase activating protein 2
KANK2 KN motif and ankyrin repeat domains 2
KIAA0125 KIAA0125
KIF14 kinesin family member 14
KRT7 keratin 7, type II
LACTB2 lactamase, beta 2
LAMA5 laminin, alpha 5
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAMLD1 mastermind-like domain containing 1
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MBOAT7 membrane bound O-acyltransferase domain containing 7
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY neuropeptide Y
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PDZK1 PDZ domain containing 1
PON2 paraoxonase 2
PPIF peptidylprolyl isomerase F
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QDPR quinoid dihydropteridine reductase
RHOBTB3 Rho-related BTB domain containing 3
RNF167 ring finger protein 167
RPA3 replication protein A3, 14kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A10 S100 calcium binding protein A10
SACS sacsin molecular chaperone
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A46 solute carrier family 25, member 46
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNX10 sorting nexin 10
STX1A syntaxin 1A (brain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WWTR1 WW domain containing transcription regulator 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble