BRD-K88573743_A443654_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

274 genes differentially expressed following the BRD-K88573743_A443654_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADCY9 adenylate cyclase 9
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHR aryl hydrocarbon receptor
AKAP8 A kinase (PRKA) anchor protein 8
ALB albumin
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD10 ankyrin repeat domain 10
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNL1 cyclin L1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDR2L cerebellar degeneration-related protein 2-like
CFB complement factor B
CHERP calcium homeostasis endoplasmic reticulum protein
CLU clusterin
COL11A1 collagen, type XI, alpha 1
CRYAB crystallin, alpha B
CXCL9 chemokine (C-X-C motif) ligand 9
CYBRD1 cytochrome b reductase 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAAM2 dishevelled associated activator of morphogenesis 2
DEFB1 defensin, beta 1
DIO1 deiodinase, iodothyronine, type I
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP14 dual specificity phosphatase 14
ELF4 E74-like factor 4 (ets domain transcription factor)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FABP1 fatty acid binding protein 1, liver
FAM46A family with sequence similarity 46, member A
FAM53C family with sequence similarity 53, member C
FAM63A family with sequence similarity 63, member A
FASTKD5 FAST kinase domains 5
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FRS2 fibroblast growth factor receptor substrate 2
FUCA1 fucosidase, alpha-L- 1, tissue
GAB2 GRB2-associated binding protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAS2 growth arrest-specific 2
GAS7 growth arrest-specific 7
GBP1 guanylate binding protein 1, interferon-inducible
GC group-specific component (vitamin D binding protein)
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GOLGA8H golgin A8 family, member H
GPR183 G protein-coupled receptor 183
GPX3 glutathione peroxidase 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBEGF heparin-binding EGF-like growth factor
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
IGKC immunoglobulin kappa constant
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
JMJD1C jumonji domain containing 1C
JUND jun D proto-oncogene
KIAA0907 KIAA0907
LAPTM4B lysosomal protein transmembrane 4 beta
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGT1 magnesium transporter 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MCTP1 multiple C2 domains, transmembrane 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MICB MHC class I polypeptide-related sequence B
MT1E metallothionein 1E
MTDH metadherin
MXRA5 matrix-remodelling associated 5
NOV nephroblastoma overexpressed
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
OPN3 opsin 3
OVGP1 oviductal glycoprotein 1, 120kDa
PARP2 poly (ADP-ribose) polymerase 2
PCBP2 poly(rC) binding protein 2
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER1 period circadian clock 1
PER2 period circadian clock 2
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLD3 phospholipase D family, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PTPRD protein tyrosine phosphatase, receptor type, D
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBM15 RNA binding motif protein 15
RBM3 RNA binding motif (RNP1, RRM) protein 3
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
RNMT RNA (guanine-7-) methyltransferase
RSBN1 round spermatid basic protein 1
RSL1D1 ribosomal L1 domain containing 1
RTN1 reticulon 1
S100A1 S100 calcium binding protein A1
SCG2 secretogranin II
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SEPT4 septin 4
SFRP4 secreted frizzled-related protein 4
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD7 SMAD family member 7
SPEN spen family transcriptional repressor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SRSF6 serine/arginine-rich splicing factor 6
SSBP2 single-stranded DNA binding protein 2
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TAPBPL TAP binding protein-like
TMOD1 tropomodulin 1
TSPAN7 tetraspanin 7
VAV3 vav 3 guanine nucleotide exchange factor
WIPF2 WAS/WASL interacting protein family, member 2
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
XYLT1 xylosyltransferase I
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331
ZNF394 zinc finger protein 394
ZNF468 zinc finger protein 468
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASPH aspartate beta-hydroxylase
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BLMH bleomycin hydrolase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3ORF14 chromosome 3 open reading frame 14
CALML5 calmodulin-like 5
CAST calpastatin
CCNA2 cyclin A2
CD24 CD24 molecule
CD58 CD58 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CETN3 centrin, EF-hand protein, 3
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COTL1 coactosin-like F-actin binding protein 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYB5R2 cytochrome b5 reductase 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP6 dual specificity phosphatase 6
DYNLT1 dynein, light chain, Tctex-type 1
DZIP3 DAZ interacting zinc finger protein 3
ELAVL1 ELAV like RNA binding protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EZR ezrin
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FN1 fibronectin 1
FST follistatin
FSTL1 follistatin-like 1
GALE UDP-galactose-4-epimerase
GRSF1 G-rich RNA sequence binding factor 1
GSTA4 glutathione S-transferase alpha 4
HAS2 hyaluronan synthase 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
INHBB inhibin, beta B
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
KDM5D lysine (K)-specific demethylase 5D
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LBR lamin B receptor
LOXL2 lysyl oxidase-like 2
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MPHOSPH6 M-phase phosphoprotein 6
MSH2 mutS homolog 2
MTERF3 mitochondrial transcription termination factor 3
MUC5B mucin 5B, oligomeric mucus/gel-forming
NDN necdin, melanoma antigen (MAGE) family member
NEBL nebulette
NIT2 nitrilase family, member 2
NKX3-1 NK3 homeobox 1
NMI N-myc (and STAT) interactor
NRP1 neuropilin 1
NUP37 nucleoporin 37kDa
ODC1 ornithine decarboxylase 1
PFKP phosphofructokinase, platelet
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PRKCD protein kinase C, delta
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PWP1 PWP1 homolog (S. cerevisiae)
RAB4A RAB4A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REXO2 RNA exonuclease 2
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
SCEL sciellin
SDC1 syndecan 1
SDC4 syndecan 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAGP small cell adhesion glycoprotein
SOSTDC1 sclerostin domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPINK5 serine peptidase inhibitor, Kazal type 5
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYT17 synaptotagmin XVII
TAGLN2 transgelin 2
TFDP1 transcription factor Dp-1
TNC tenascin C
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPRKB TP53RK binding protein
TRIOBP TRIO and F-actin binding protein
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXNDC9 thioredoxin domain containing 9
UGP2 UDP-glucose pyrophosphorylase 2
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VCAN versican
WDR61 WD repeat domain 61
WNT5A wingless-type MMTV integration site family, member 5A