BRD-K88573743_A443654_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-K88573743_A443654_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ACOT13 acyl-CoA thioesterase 13
ADAM12 ADAM metallopeptidase domain 12
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BACE2 beta-site APP-cleaving enzyme 2
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C1ORF54 chromosome 1 open reading frame 54
C1R complement component 1, r subcomponent
C3 complement component 3
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD320 CD320 molecule
CD48 CD48 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COG7 component of oligomeric golgi complex 7
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
FBLN1 fibulin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FRZB frizzled-related protein
GAA glucosidase, alpha; acid
GADD45B growth arrest and DNA-damage-inducible, beta
GHR growth hormone receptor
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGN5 high mobility group nucleosome binding domain 5
HOXA10 homeobox A10
HTRA1 HtrA serine peptidase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IL2RG interleukin 2 receptor, gamma
ISYNA1 inositol-3-phosphate synthase 1
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JAG1 jagged 1
LAMP3 lysosomal-associated membrane protein 3
LAMP5 lysosomal-associated membrane protein family, member 5
LGMN legumain
LTBP1 latent transforming growth factor beta binding protein 1
MAPT microtubule-associated protein tau
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS1 Meis homeobox 1
MFAP2 microfibrillar-associated protein 2
MN1 meningioma (disrupted in balanced translocation) 1
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUCB1 nucleobindin 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PDE1A phosphodiesterase 1A, calmodulin-dependent
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PRKCB protein kinase C, beta
PRKCQ protein kinase C, theta
PROS1 protein S (alpha)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
SCG2 secretogranin II
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3GL3 SH3-domain GRB2-like 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMYD3 SET and MYND domain containing 3
SNAP25 synaptosomal-associated protein, 25kDa
SORD sorbitol dehydrogenase
SPARCL1 SPARC-like 1 (hevin)
SSR4 signal sequence receptor, delta
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TYROBP TYRO protein tyrosine kinase binding protein
VWF von Willebrand factor
WBP5 WW domain binding protein 5
XIST X inactive specific transcript (non-protein coding)
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BLVRA biliverdin reductase A
BTG1 B-cell translocation gene 1, anti-proliferative
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CCNB1 cyclin B1
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHMP7 charged multivesicular body protein 7
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5A eukaryotic translation initiation factor 5A
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FZD7 frizzled class receptor 7
GLOD4 glyoxalase domain containing 4
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KCTD5 potassium channel tetramerization domain containing 5
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT15 keratin 15, type I
LBR lamin B receptor
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKI67 marker of proliferation Ki-67
NOTCH2 notch 2
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PCNA proliferating cell nuclear antigen
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTX3 pentraxin 3, long
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX9 SRY (sex determining region Y)-box 9
SPDL1 spindle apparatus coiled-coil protein 1
SPP1 secreted phosphoprotein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STXBP1 syntaxin binding protein 1
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMPO thymopoietin
TRAPPC3 trafficking protein particle complex 3
TSPYL5 TSPY-like 5
UBE2C ubiquitin-conjugating enzyme E2C
UBE3C ubiquitin protein ligase E3C
USP1 ubiquitin specific peptidase 1
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
XPO7 exportin 7