BRD-K88573743_A443654_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K88573743_A443654_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMPD3 adenosine monophosphate deaminase 3
APOD apolipoprotein D
CALD1 caldesmon 1
CAV2 caveolin 2
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
DAPK1 death-associated protein kinase 1
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
FABP1 fatty acid binding protein 1, liver
FAP fibroblast activation protein, alpha
FGF9 fibroblast growth factor 9
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GMDS GDP-mannose 4,6-dehydratase
GPI glucose-6-phosphate isomerase
GPM6A glycoprotein M6A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IGLV1-40 immunoglobulin lambda variable 1-40
INHBA inhibin, beta A
LOX lysyl oxidase
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAST2 microtubule associated serine/threonine kinase 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MT1M metallothionein 1M
MUC4 mucin 4, cell surface associated
MXRA7 matrix-remodelling associated 7
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PCCA propionyl CoA carboxylase, alpha polypeptide
PCDH9 protocadherin 9
PCSK5 proprotein convertase subtilisin/kexin type 5
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSPH phosphoserine phosphatase
RAB2A RAB2A, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SRPX sushi-repeat containing protein, X-linked
TFPI2 tissue factor pathway inhibitor 2
THBS4 thrombospondin 4
TMEM45A transmembrane protein 45A
TSPAN8 tetraspanin 8
TTC3 tetratricopeptide repeat domain 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHR aryl hydrocarbon receptor
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAMBI BMP and activin membrane-bound inhibitor
BST2 bone marrow stromal cell antigen 2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLP1 cleavage and polyadenylation factor I subunit 1
CPB1 carboxypeptidase B1 (tissue)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
ESR1 estrogen receptor 1
FASTKD5 FAST kinase domains 5
FBP1 fructose-1,6-bisphosphatase 1
GATA3 GATA binding protein 3
GNAS GNAS complex locus
GSTM1 glutathione S-transferase mu 1
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFNGR1 interferon gamma receptor 1
IGL immunoglobulin lambda locus
MCL1 myeloid cell leukemia 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLK2 polo-like kinase 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAP2B RAP2B, member of RAS oncogene family
RPP38 ribonuclease P/MRP 38kDa subunit
SCARB2 scavenger receptor class B, member 2
SESN1 sestrin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX4 SRY (sex determining region Y)-box 4
SUB1 SUB1 homolog (S. cerevisiae)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNS3 tensin 3
TSKU tsukushi, small leucine rich proteoglycan
VCAM1 vascular cell adhesion molecule 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217