BRD-K88573743_A443654_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

239 genes differentially expressed following the BRD-K88573743_A443654_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP8 A kinase (PRKA) anchor protein 8
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASCC3 activating signal cointegrator 1 complex subunit 3
ATMIN ATM interactor
BACE1 beta-site APP-cleaving enzyme 1
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BLCAP bladder cancer associated protein
BTG3 BTG family, member 3
C6ORF48 chromosome 6 open reading frame 48
CD36 CD36 molecule (thrombospondin receptor)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CGRRF1 cell growth regulator with ring finger domain 1
CHERP calcium homeostasis endoplasmic reticulum protein
CLEC2B C-type lectin domain family 2, member B
CST3 cystatin C
CTSZ cathepsin Z
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
DFNA5 deafness, autosomal dominant 5
DNMBP dynamin binding protein
DST dystonin
DUSP14 dual specificity phosphatase 14
DUSP7 dual specificity phosphatase 7
EIF3E eukaryotic translation initiation factor 3, subunit E
FABP4 fatty acid binding protein 4, adipocyte
FAM110B family with sequence similarity 110, member B
FAM46A family with sequence similarity 46, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FJX1 four jointed box 1 (Drosophila)
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45A growth arrest and DNA-damage-inducible, alpha
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPATCH8 G patch domain containing 8
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GSN gelsolin
HIST1H2BK histone cluster 1, H2bk
HLA-C major histocompatibility complex, class I, C
IGFBP7 insulin-like growth factor binding protein 7
INPP1 inositol polyphosphate-1-phosphatase
IRS2 insulin receptor substrate 2
JMJD1C jumonji domain containing 1C
KANK1 KN motif and ankyrin repeat domains 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0907 KIAA0907
KLF4 Kruppel-like factor 4 (gut)
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LTBP2 latent transforming growth factor beta binding protein 2
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MALT1 MALT1 paracaspase
MCTP1 multiple C2 domains, transmembrane 1
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
MPPED2 metallophosphoesterase domain containing 2
MUC1 mucin 1, cell surface associated
MYO6 myosin VI
NAP1L3 nucleosome assembly protein 1-like 3
NAV3 neuron navigator 3
NPIPB3 nuclear pore complex interacting protein family, member B3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OLFML2A olfactomedin-like 2A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PBX3 pre-B-cell leukemia homeobox 3
PDE10A phosphodiesterase 10A
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PER2 period circadian clock 2
PLA2G15 phospholipase A2, group XV
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PNMA1 paraneoplastic Ma antigen 1
PNMAL1 paraneoplastic Ma antigen family-like 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRAF2 PRA1 domain family, member 2
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTX3 pentraxin 3, long
RIPK2 receptor-interacting serine-threonine kinase 2
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPL28 ribosomal protein L28
RPL36 ribosomal protein L36
RSL1D1 ribosomal L1 domain containing 1
SCG5 secretogranin V
SCPEP1 serine carboxypeptidase 1
SEPT4 septin 4
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD3 SMAD family member 3
SPON1 spondin 1, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
SRRM2 serine/arginine repetitive matrix 2
SYBU syntabulin (syntaxin-interacting)
TCERG1 transcription elongation regulator 1
TFF1 trefoil factor 1
THBD thrombomodulin
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM30B transmembrane protein 30B
TRIB2 tribbles pseudokinase 2
TRPS1 trichorhinophalangeal syndrome I
UBR5 ubiquitin protein ligase E3 component n-recognin 5
VIM vimentin
VLDLR very low density lipoprotein receptor
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB43 zinc finger and BTB domain containing 43
ZNF264 zinc finger protein 264
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
ANXA4 annexin A4
ANXA7 annexin A7
APOH apolipoprotein H (beta-2-glycoprotein I)
ASL argininosuccinate lyase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC6 cell division cycle 6
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL6A2 collagen, type VI, alpha 2
CPB2 carboxypeptidase B2 (plasma)
CYB5A cytochrome b5 type A (microsomal)
CYB5R2 cytochrome b5 reductase 2
DAPK1 death-associated protein kinase 1
DCK deoxycytidine kinase
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL2 dihydropyrimidinase-like 2
DYNLT1 dynein, light chain, Tctex-type 1
EIF5A eukaryotic translation initiation factor 5A
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FST follistatin
FSTL1 follistatin-like 1
GALE UDP-galactose-4-epimerase
GLRX glutaredoxin (thioltransferase)
GTPBP8 GTP-binding protein 8 (putative)
HCAR3 hydroxycarboxylic acid receptor 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LBR lamin B receptor
LSP1 lymphocyte-specific protein 1
LTF lactotransferrin
LUM lumican
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MCM5 minichromosome maintenance complex component 5
MSH2 mutS homolog 2
MSMB microseminoprotein, beta-
NDC80 NDC80 kinetochore complex component
NMI N-myc (and STAT) interactor
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
ORM1 orosomucoid 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCNA proliferating cell nuclear antigen
PKP1 plakophilin 1
PPA2 pyrophosphatase (inorganic) 2
PRODH proline dehydrogenase (oxidase) 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PTMA prothymosin, alpha
RABGAP1L RAB GTPase activating protein 1-like
RANBP1 RAN binding protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
RGS13 regulator of G-protein signaling 13
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
RRBP1 ribosome binding protein 1
SDC1 syndecan 1
SDC4 syndecan 4
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAMBP STAM binding protein
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TACSTD2 tumor-associated calcium signal transducer 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TPM1 tropomyosin 1 (alpha)
TUBA1A tubulin, alpha 1a
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
WNT5A wingless-type MMTV integration site family, member 5A
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta