BRD-K88573743_A443654_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

255 genes differentially expressed following the BRD-K88573743_A443654_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAMDEC1 ADAM-like, decysin 1
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
AIM2 absent in melanoma 2
ANGPTL2 angiopoietin-like 2
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
ARHGAP32 Rho GTPase activating protein 32
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BTG2 BTG family, member 2
C3 complement component 3
C3AR1 complement component 3a receptor 1
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL8 chemokine (C-C motif) ligand 8
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CCRL2 chemokine (C-C motif) receptor-like 2
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD84 CD84 molecule
CD93 CD93 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CEP70 centrosomal protein 70kDa
CES2 carboxylesterase 2
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC10A C-type lectin domain family 10, member A
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DCN decorin
DENND1B DENN/MADD domain containing 1B
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLG3 discs, large homolog 3 (Drosophila)
DUSP4 dual specificity phosphatase 4
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FAM107A family with sequence similarity 107, member A
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGL2 fibrinogen-like 2
FLT1 fms-related tyrosine kinase 1
FMO3 flavin containing monooxygenase 3
FOXF2 forkhead box F2
FRY furry homolog (Drosophila)
FRZB frizzled-related protein
GAGE3 G antigen 3
GFOD1 glucose-fructose oxidoreductase domain containing 1
GPNMB glycoprotein (transmembrane) nmb
GPRASP1 G protein-coupled receptor associated sorting protein 1
GSDMB gasdermin B
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IDO1 indoleamine 2,3-dioxygenase 1
IGSF6 immunoglobulin superfamily, member 6
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IRF6 interferon regulatory factor 6
ITM2A integral membrane protein 2A
JAG1 jagged 1
JUP junction plakoglobin
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL24 kelch-like family member 24
KLK10 kallikrein-related peptidase 10
LAMA4 laminin, alpha 4
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NID1 nidogen 1
NMU neuromedin U
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PARM1 prostate androgen-regulated mucin-like protein 1
PAX6 paired box 6
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4A phosphodiesterase 4A, cAMP-specific
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PGAP1 post-GPI attachment to proteins 1
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PPARG peroxisome proliferator-activated receptor gamma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS16 protease, serine, 16 (thymus)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RBP4 retinol binding protein 4, plasma
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RLN1 relaxin 1
RNASE6 ribonuclease, RNase A family, k6
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF130 ring finger protein 130
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SIDT1 SID1 transmembrane family, member 1
SLAMF8 SLAM family member 8
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOX2 SRY (sex determining region Y)-box 2
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSPN sarcospan
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
TEK TEK tyrosine kinase, endothelial
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFA transforming growth factor, alpha
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
UVRAG UV radiation resistance associated
VSNL1 visinin-like 1
VWA5A von Willebrand factor A domain containing 5A
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
ANXA5 annexin A5
ANXA6 annexin A6
ARMCX6 armadillo repeat containing, X-linked 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIN1 bridging integrator 1
BST2 bone marrow stromal cell antigen 2
C8ORF4 chromosome 8 open reading frame 4
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
EDF1 endothelial differentiation-related factor 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GRSF1 G-rich RNA sequence binding factor 1
HAT1 histone acetyltransferase 1
HN1L hematological and neurological expressed 1-like
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
ILK integrin-linked kinase
KIAA0368 KIAA0368
KRT10 keratin 10, type I
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MYBPC1 myosin binding protein C, slow type
NEK7 NIMA-related kinase 7
OXTR oxytocin receptor
PDLIM2 PDZ and LIM domain 2 (mystique)
PHB prohibitin
PLK1 polo-like kinase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PYCR1 pyrroline-5-carboxylate reductase 1
REXO2 RNA exonuclease 2
S100A11 S100 calcium binding protein A11
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STMN1 stathmin 1
TBC1D4 TBC1 domain family, member 4
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TPM1 tropomyosin 1 (alpha)
TRAPPC3 trafficking protein particle complex 3
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
XBP1 X-box binding protein 1