BRD-K88560311_rucaparib_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

51 genes differentially expressed following the BRD-K88560311_rucaparib_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AREG amphiregulin
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
EREG epiregulin
FGFR2 fibroblast growth factor receptor 2
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
IER5 immediate early response 5
IGFBP1 insulin-like growth factor binding protein 1
IL1R2 interleukin 1 receptor, type II
INHBB inhibin, beta B
JAG1 jagged 1
MLF1 myeloid leukemia factor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEBL nebulette
PLA2G16 phospholipase A2, group XVI
PXMP2 peroxisomal membrane protein 2, 22kDa
RET ret proto-oncogene
SCCPDH saccharopine dehydrogenase (putative)
SCGB2A2 secretoglobin, family 2A, member 2
TBX2 T-box 2
TUBB2B tubulin, beta 2B class IIb
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28

decreased expression

Symbol Name
CD44 CD44 molecule (Indian blood group)
EHD3 EH-domain containing 3
FAM63A family with sequence similarity 63, member A
FKBP11 FK506 binding protein 11, 19 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
H2AFV H2A histone family, member V
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
ITGA6 integrin, alpha 6
KRT13 keratin 13, type I
LTBP2 latent transforming growth factor beta binding protein 2
LYZ lysozyme
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
NOX4 NADPH oxidase 4
PAM peptidylglycine alpha-amidating monooxygenase
PMM2 phosphomannomutase 2
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
VDAC1 voltage-dependent anion channel 1
VWF von Willebrand factor