BRD-K88544581_CI 976_A549_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K88544581_CI 976_A549_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AGR2 anterior gradient 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE40 basic helix-loop-helix family, member e40
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFLAR CASP8 and FADD-like apoptosis regulator
COL9A3 collagen, type IX, alpha 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FBXO11 F-box protein 11
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IL1RAP interleukin 1 receptor accessory protein
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LARP6 La ribonucleoprotein domain family, member 6
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAST4 microtubule associated serine/threonine kinase family member 4
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAM peptidylglycine alpha-amidating monooxygenase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIPK2 receptor-interacting serine-threonine kinase 2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
SYNJ2 synaptojanin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
THBS1 thrombospondin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ATF5 activating transcription factor 5
B3GNT1
BLCAP bladder cancer associated protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEP68 centrosomal protein 68kDa
CLC Charcot-Leyden crystal galectin
CXCL14 chemokine (C-X-C motif) ligand 14
DEGS1 delta(4)-desaturase, sphingolipid 1
DPYSL2 dihydropyrimidinase-like 2
EDNRB endothelin receptor type B
FCGBP Fc fragment of IgG binding protein
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GINS1 GINS complex subunit 1 (Psf1 homolog)
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HSPA1A heat shock 70kDa protein 1A
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KLK10 kallikrein-related peptidase 10
MMP9 matrix metallopeptidase 9
NMU neuromedin U
NUSAP1 nucleolar and spindle associated protein 1
PBX3 pre-B-cell leukemia homeobox 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTTG1 pituitary tumor-transforming 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TBC1D4 TBC1 domain family, member 4
UBE3C ubiquitin protein ligase E3C