BRD-K88378636_withaferin-a_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K88378636_withaferin-a_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV1 ets variant 1
EVL Enah/Vasp-like
GOLM1 golgi membrane protein 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL17RB interleukin 17 receptor B
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KRT7 keratin 7, type II
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K5 mitogen-activated protein kinase kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
NRGN neurogranin (protein kinase C substrate, RC3)
PDE2A phosphodiesterase 2A, cGMP-stimulated
PENK proenkephalin
PNKP polynucleotide kinase 3'-phosphatase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRR15L proline rich 15-like
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC38A1 solute carrier family 38, member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TES testin LIM domain protein
TIMELESS timeless circadian clock
TMSB15A thymosin beta 15a
VWA5A von Willebrand factor A domain containing 5A
WBP5 WW domain binding protein 5
WDR7 WD repeat domain 7
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AKAP1 A kinase (PRKA) anchor protein 1
ALCAM activated leukocyte cell adhesion molecule
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FZD7 frizzled class receptor 7
GCH1 GTP cyclohydrolase 1
HES1 hes family bHLH transcription factor 1
HLA-B major histocompatibility complex, class I, B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1B interleukin 1, beta
IL32 interleukin 32
IRS2 insulin receptor substrate 2
ITFG1 integrin alpha FG-GAP repeat containing 1
KANK1 KN motif and ankyrin repeat domains 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY96 lymphocyte antigen 96
NAV2 neuron navigator 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRN1 neuritin 1
PFDN4 prefoldin subunit 4
SDC4 syndecan 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRY2 sprouty homolog 2 (Drosophila)
TFRC transferrin receptor
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM2D1 TM2 domain containing 1
TMEM14B transmembrane protein 14B
TSPAN5 tetraspanin 5