BRD-K88378636_withaferin-a_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K88378636_withaferin-a_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BTG2 BTG family, member 2
C2 complement component 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CHEK2 checkpoint kinase 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
CRELD2 cysteine-rich with EGF-like domains 2
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ETV1 ets variant 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX2 glutathione peroxidase 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSDMB gasdermin B
H1FX H1 histone family, member X
HBB hemoglobin, beta
HIST1H2BG histone cluster 1, H2bg
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0355 KIAA0355
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LPL lipoprotein lipase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRN1 neuritin 1
ORC1 origin recognition complex, subunit 1
PENK proenkephalin
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLBD1 phospholipase B domain containing 1
PNMA2 paraneoplastic Ma antigen 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SORBS1 sorbin and SH3 domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STMN2 stathmin 2
TAC1 tachykinin, precursor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFA transforming growth factor, alpha
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TSPAN8 tetraspanin 8
TYMP thymidine phosphorylase
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP6NL USP6 N-terminal like
WNT5B wingless-type MMTV integration site family, member 5B
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ALB albumin
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BAMBI BMP and activin membrane-bound inhibitor
BHLHE41 basic helix-loop-helix family, member e41
C2CD2 C2 calcium-dependent domain containing 2
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CAPN3 calpain 3, (p94)
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CES1 carboxylesterase 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL4A5 collagen, type IV, alpha 5
CTBP2 C-terminal binding protein 2
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DSP desmoplakin
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
F2R coagulation factor II (thrombin) receptor
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FNBP1 formin binding protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GRAMD3 GRAM domain containing 3
HAT1 histone acetyltransferase 1
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
KRT81 keratin 81, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LITAF lipopolysaccharide-induced TNF factor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYZ lysozyme
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MPZL2 myelin protein zero-like 2
MXRA7 matrix-remodelling associated 7
MYLK myosin light chain kinase
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
OPN3 opsin 3
OXA1L oxidase (cytochrome c) assembly 1-like
PCP4 Purkinje cell protein 4
PLCB4 phospholipase C, beta 4
PPAP2C phosphatidic acid phosphatase type 2C
PRKD3 protein kinase D3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP4 retinol binding protein 4, plasma
RPL31 ribosomal protein L31
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TRD T cell receptor delta locus
TRPS1 trichorhinophalangeal syndrome I
VIM vimentin
VLDLR very low density lipoprotein receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)
ZDHHC6 zinc finger, DHHC-type containing 6