BRD-K88378636_withaferin-a_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

222 genes differentially expressed following the BRD-K88378636_withaferin-a_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAM12 ADAM metallopeptidase domain 12
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BTG2 BTG family, member 2
CACYBP calcyclin binding protein
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CD99 CD99 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHPT1 choline phosphotransferase 1
CLDN10 claudin 10
CP ceruloplasmin (ferroxidase)
CRISP3 cysteine-rich secretory protein 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXC1 forkhead box C1
GABPB1 GA binding protein transcription factor, beta subunit 1
GALC galactosylceramidase
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GJA1 gap junction protein, alpha 1, 43kDa
GPATCH8 G patch domain containing 8
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KRT14 keratin 14, type I
KRT19 keratin 19, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LRRC16A leucine rich repeat containing 16A
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAOB monoamine oxidase B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPO myeloperoxidase
MSX1 msh homeobox 1
MTUS1 microtubule associated tumor suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIAS2 protein inhibitor of activated STAT, 2
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCH protein kinase C, eta
PROM1 prominin 1
RAB25 RAB25, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RPL39L ribosomal protein L39-like
SEC24A SEC24 family member A
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM110 transmembrane protein 110
TMEM47 transmembrane protein 47
TRBC1 T cell receptor beta constant 1
TXNRD1 thioredoxin reductase 1
WBP2 WW domain binding protein 2
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZNF394 zinc finger protein 394

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AKAP1 A kinase (PRKA) anchor protein 1
ALCAM activated leukocyte cell adhesion molecule
ALOX15B arachidonate 15-lipoxygenase, type B
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
BHLHE41 basic helix-loop-helix family, member e41
C1ORF106 chromosome 1 open reading frame 106
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CCNF cyclin F
CD24 CD24 molecule
CD93 CD93 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CELF2 CUGBP, Elav-like family member 2
CLC Charcot-Leyden crystal galectin
CLTB clathrin, light chain B
COG2 component of oligomeric golgi complex 2
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CSNK1E casein kinase 1, epsilon
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DARS aspartyl-tRNA synthetase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEGS1 delta(4)-desaturase, sphingolipid 1
DES desmin
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM120A family with sequence similarity 120A
FHL1 four and a half LIM domains 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GPX3 glutathione peroxidase 3
GSN gelsolin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HMGN4 high mobility group nucleosomal binding domain 4
HOXA10 homeobox A10
HOXA5 homeobox A5
IER3 immediate early response 3
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
IL33 interleukin 33
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
JADE2 jade family PHD finger 2
LGALS1 lectin, galactoside-binding, soluble, 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP16 NOP16 nucleolar protein
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ORM1 orosomucoid 1
PDE9A phosphodiesterase 9A
PDLIM3 PDZ and LIM domain 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLN phospholamban
PNMA2 paraneoplastic Ma antigen 2
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PTCH1 patched 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS5 regulator of G-protein signaling 5
RNF43 ring finger protein 43
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SF1 splicing factor 1
SMAD3 SMAD family member 3
SOX11 SRY (sex determining region Y)-box 11
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACC2 transforming, acidic coiled-coil containing protein 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNS3 tensin 3
TUBB6 tubulin, beta 6 class V
VCAN versican
WLS wntless Wnt ligand secretion mediator