BRD-K88378636_withaferin-a_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

286 genes differentially expressed following the BRD-K88378636_withaferin-a_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANXA1 annexin A1
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
CA2 carbonic anhydrase II
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAPN2 calpain 2, (m/II) large subunit
CBR1 carbonyl reductase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DPP4 dipeptidyl-peptidase 4
DSG3 desmoglein 3
EGFR epidermal growth factor receptor
EMP3 epithelial membrane protein 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GMPR guanosine monophosphate reductase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAS GNAS complex locus
GOLM1 golgi membrane protein 1
GPC1 glypican 1
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT6A keratin 6A, type II
KYNU kynureninase
LAMA3 laminin, alpha 3
LHFPL2 lipoma HMGIC fusion partner-like 2
MALT1 MALT1 paracaspase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLPH melanophilin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NINJ1 ninjurin 1
NOSIP nitric oxide synthase interacting protein
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP3 nuclear receptor interacting protein 3
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
PERP PERP, TP53 apoptosis effector
PGC progastricsin (pepsinogen C)
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMP22 peripheral myelin protein 22
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGES prostaglandin E synthase
RBP1 retinol binding protein 1, cellular
S100A10 S100 calcium binding protein A10
SERTAD2 SERTA domain containing 2
SFN stratifin
SIX1 SIX homeobox 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SMOX spermine oxidase
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
TACC2 transforming, acidic coiled-coil containing protein 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNPO1 transportin 1
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADGRG6 adhesion G protein-coupled receptor G6
ADGRL4 adhesion G protein-coupled receptor L4
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHCY adenosylhomocysteinase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOLD1 apolipoprotein L domain containing 1
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASS1 argininosuccinate synthase 1
ATP10B ATPase, class V, type 10B
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCHE butyrylcholinesterase
C6 complement component 6
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CAT catalase
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CCNE2 cyclin E2
CCNG1 cyclin G1
CD200 CD200 molecule
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFH complement factor H
CLIC3 chloride intracellular channel 3
COBLL1 cordon-bleu WH2 repeat protein-like 1
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYFIP1 cytoplasmic FMR1 interacting protein 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DPYD dihydropyrimidine dehydrogenase
ERBB3 erb-b2 receptor tyrosine kinase 3
EVL Enah/Vasp-like
F12 coagulation factor XII (Hageman factor)
F2R coagulation factor II (thrombin) receptor
FABP1 fatty acid binding protein 1, liver
FAM13A family with sequence similarity 13, member A
FILIP1L filamin A interacting protein 1-like
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GGCT gamma-glutamylcyclotransferase
GIMAP6 GTPase, IMAP family member 6
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GREM1 gremlin 1, DAN family BMP antagonist
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HADH hydroxyacyl-CoA dehydrogenase
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN3 high mobility group nucleosomal binding domain 3
HNMT histamine N-methyltransferase
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KANK1 KN motif and ankyrin repeat domains 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0101 KIAA0101
KRT20 keratin 20, type I
LDHB lactate dehydrogenase B
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
LUM lumican
MAGED1 melanoma antigen family D1
MBP myelin basic protein
METTL7A methyltransferase like 7A
MFSD10 major facilitator superfamily domain containing 10
MME membrane metallo-endopeptidase
MYLK myosin light chain kinase
MYO5C myosin VC
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNT nicotinamide nucleotide transhydrogenase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NREP neuronal regeneration related protein
NRN1 neuritin 1
NUP210 nucleoporin 210kDa
OLFM4 olfactomedin 4
PAM peptidylglycine alpha-amidating monooxygenase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
PLS3 plastin 3
PLSCR4 phospholipid scramblase 4
PPA1 pyrophosphatase (inorganic) 1
PRKCA protein kinase C, alpha
PRR15L proline rich 15-like
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB31 RAB31, member RAS oncogene family
RBM3 RNA binding motif (RNP1, RRM) protein 3
RELN reelin
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RRAGD Ras-related GTP binding D
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPB surfactant protein B
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3BGRL SH3 domain binding glutamate-rich protein like
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TJP2 tight junction protein 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMPO thymopoietin
TNS1 tensin 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TSPAN12 tetraspanin 12
TSPAN8 tetraspanin 8
TTR transthyretin
TXNIP thioredoxin interacting protein
UBL3 ubiquitin-like 3
UPK3B uroplakin 3B
VCAM1 vascular cell adhesion molecule 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF22 zinc finger protein 22