BRD-K88378636_withaferin-a_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K88378636_withaferin-a_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
ANKRD10 ankyrin repeat domain 10
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
C4BPA complement component 4 binding protein, alpha
CD69 CD69 molecule
CLDN10 claudin 10
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR1 early growth response 1
EGR2 early growth response 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IDS iduronate 2-sulfatase
IER2 immediate early response 2
IER5 immediate early response 5
LYZ lysozyme
MUC5B mucin 5B, oligomeric mucus/gel-forming
NELL2 NEL-like 2 (chicken)
NR4A1 nuclear receptor subfamily 4, group A, member 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PITX1 paired-like homeodomain 1
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
PTPRO protein tyrosine phosphatase, receptor type, O
RGS1 regulator of G-protein signaling 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFTPB surfactant protein B
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
TPPP3 tubulin polymerization-promoting protein family member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFS1 Wolfram syndrome 1 (wolframin)
ZFP36 ZFP36 ring finger protein
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ARL4C ADP-ribosylation factor-like 4C
BASP1 brain abundant, membrane attached signal protein 1
CCDC85B coiled-coil domain containing 85B
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CNN3 calponin 3, acidic
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DACH1 dachshund family transcription factor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FAM171A1 family with sequence similarity 171, member A1
FXYD3 FXYD domain containing ion transport regulator 3
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HIST3H2A histone cluster 3, H2a
HOXA10 homeobox A10
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LAMA3 laminin, alpha 3
MAP7 microtubule-associated protein 7
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MMP9 matrix metallopeptidase 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID2 nidogen 2 (osteonidogen)
NTS neurotensin
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PSD3 pleckstrin and Sec7 domain containing 3
RAB13 RAB13, member RAS oncogene family
S100A9 S100 calcium binding protein A9
SPP1 secreted phosphoprotein 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)