BRD-K88378636_withaferin-a_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K88378636_withaferin-a_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSRP2 cysteine and glycine-rich protein 2
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FAM46C family with sequence similarity 46, member C
FBXL12 F-box and leucine-rich repeat protein 12
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD5 FXYD domain containing ion transport regulator 5
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GEM GTP binding protein overexpressed in skeletal muscle
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MEIS2 Meis homeobox 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PEG10 paternally expressed 10
PER1 period circadian clock 1
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
RGS1 regulator of G-protein signaling 1
RPL10 ribosomal protein L10
RSRP1 arginine/serine-rich protein 1
SIK1 salt-inducible kinase 1
SRSF7 serine/arginine-rich splicing factor 7
SYNM synemin, intermediate filament protein
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
TSPYL2 TSPY-like 2
TWIST1 twist family bHLH transcription factor 1
WARS tryptophanyl-tRNA synthetase
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AGTR1 angiotensin II receptor, type 1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA7 annexin A7
ARHGAP29 Rho GTPase activating protein 29
BMP2 bone morphogenetic protein 2
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CD9 CD9 molecule
CHGB chromogranin B
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DCLK1 doublecortin-like kinase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
EPHA3 EPH receptor A3
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM134B family with sequence similarity 134, member B
FASTKD5 FAST kinase domains 5
FERMT1 fermitin family member 1
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICAM1 intercellular adhesion molecule 1
IFNGR1 interferon gamma receptor 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAV integrin, alpha V
JAG1 jagged 1
KRT19 keratin 19, type I
LAMC2 laminin, gamma 2
LTF lactotransferrin
LXN latexin
MLF1 myeloid leukemia factor 1
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PDGFA platelet-derived growth factor alpha polypeptide
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
PNMA1 paraneoplastic Ma antigen 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSD3 pleckstrin and Sec7 domain containing 3
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100A11 S100 calcium binding protein A11
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC4 syndecan 4
SNAP25 synaptosomal-associated protein, 25kDa
SOD2 superoxide dismutase 2, mitochondrial
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACSTD2 tumor-associated calcium signal transducer 2
TJP2 tight junction protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
VCAM1 vascular cell adhesion molecule 1