BRD-K88378636_withaferin-a_HME1_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K88378636_withaferin-a_HME1_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CETN3 centrin, EF-hand protein, 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN10 claudin 10
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR1 early growth response 1
EGR3 early growth response 3
FGFR2 fibroblast growth factor receptor 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUCA1 fucosidase, alpha-L- 1, tissue
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGL immunoglobulin lambda locus
IVNS1ABP influenza virus NS1A binding protein
LDB2 LIM domain binding 2
LMO2 LIM domain only 2 (rhombotin-like 1)
MGLL monoglyceride lipase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NPY1R neuropeptide Y receptor Y1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
PPOX protoporphyrinogen oxidase
PRKCB protein kinase C, beta
PSPH phosphoserine phosphatase
SEPW1 selenoprotein W, 1
SIK1 salt-inducible kinase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TMEM97 transmembrane protein 97
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADAM28 ADAM metallopeptidase domain 28
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BIRC3 baculoviral IAP repeat containing 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD58 CD58 molecule
CLIC3 chloride intracellular channel 3
CLTB clathrin, light chain B
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DSC2 desmocollin 2
EMP1 epithelial membrane protein 1
EMP2 epithelial membrane protein 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FCGBP Fc fragment of IgG binding protein
FERMT2 fermitin family member 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GCH1 GTP cyclohydrolase 1
GJA1 gap junction protein, alpha 1, 43kDa
GRB10 growth factor receptor-bound protein 10
HIPK3 homeodomain interacting protein kinase 3
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IFNGR1 interferon gamma receptor 1
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAV integrin, alpha V
JAG1 jagged 1
KLHL21 kelch-like family member 21
LCN2 lipocalin 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MMP9 matrix metallopeptidase 9
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NDRG1 N-myc downstream regulated 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPIF peptidylprolyl isomerase F
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PSME4 proteasome (prosome, macropain) activator subunit 4
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SMAD7 SMAD family member 7
SPHK1 sphingosine kinase 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM16 tripartite motif containing 16
UGDH UDP-glucose 6-dehydrogenase
YAP1 Yes-associated protein 1