BRD-K88378636_withaferin-a_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

320 genes differentially expressed following the BRD-K88378636_withaferin-a_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ABHD2 abhydrolase domain containing 2
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALAS1 5'-aminolevulinate synthase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
CD163 CD163 molecule
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHMP1B charged multivesicular body protein 1B
CNOT4 CCR4-NOT transcription complex, subunit 4
CTSA cathepsin A
CTSB cathepsin B
CTSL cathepsin L
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EGR1 early growth response 1
ELL2 elongation factor, RNA polymerase II, 2
FAM46A family with sequence similarity 46, member A
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GSTA1 glutathione S-transferase alpha 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IGFBP6 insulin-like growth factor binding protein 6
ITGA6 integrin, alpha 6
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
LPIN1 lipin 1
LTF lactotransferrin
MAOA monoamine oxidase A
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MERTK MER proto-oncogene, tyrosine kinase
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP3 matrix metallopeptidase 3
NEFL neurofilament, light polypeptide
NKX3-1 NK3 homeobox 1
NMRK1 nicotinamide riboside kinase 1
NPC1 Niemann-Pick disease, type C1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
ODC1 ornithine decarboxylase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PLD3 phospholipase D family, member 3
PLIN2 perilipin 2
PMP22 peripheral myelin protein 22
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTX3 pentraxin 3, long
RB1CC1 RB1-inducible coiled-coil 1
RBKS ribokinase
RCAN1 regulator of calcineurin 1
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RND3 Rho family GTPase 3
RRAGC Ras-related GTP binding C
RYBP RING1 and YY1 binding protein
S100A11 S100 calcium binding protein A11
SAT1 spermidine/spermine N1-acetyltransferase 1
SECISBP2L SECIS binding protein 2-like
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SERTAD2 SERTA domain containing 2
SET SET nuclear proto-oncogene
SFN stratifin
SH3BGR SH3 domain binding glutamate-rich protein
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
THBS4 thrombospondin 4
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNPO1 transportin 1
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRIO trio Rho guanine nucleotide exchange factor
TSPYL5 TSPY-like 5
TXNRD1 thioredoxin reductase 1
UBXN7 UBX domain protein 7
UGDH UDP-glucose 6-dehydrogenase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP6NL USP6 N-terminal like
VAT1 vesicle amine transport 1
WIF1 WNT inhibitory factor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
AHCY adenosylhomocysteinase
ALB albumin
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ASRGL1 asparaginase like 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
C10ORF10 chromosome 10 open reading frame 10
C1ORF106 chromosome 1 open reading frame 106
C3 complement component 3
C7 complement component 7
CAPN1 calpain 1, (mu/I) large subunit
CCL20 chemokine (C-C motif) ligand 20
CCNE2 cyclin E2
CD200 CD200 molecule
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFH complement factor H
CFI complement factor I
CHGB chromogranin B
CKB creatine kinase, brain
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
CP ceruloplasmin (ferroxidase)
CRIP2 cysteine-rich protein 2
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DLK1 delta-like 1 homolog (Drosophila)
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
ECT2 epithelial cell transforming 2
EDNRA endothelin receptor type A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FCGBP Fc fragment of IgG binding protein
FEN1 flap structure-specific endonuclease 1
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GPER1 G protein-coupled estrogen receptor 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HNMT histamine N-methyltransferase
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IPO5 importin 5
IRS2 insulin receptor substrate 2
ISYNA1 inositol-3-phosphate synthase 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUP junction plakoglobin
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT8 keratin 8, type II
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LITAF lipopolysaccharide-induced TNF factor
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK13 mitogen-activated protein kinase 13
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MDK midkine (neurite growth-promoting factor 2)
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MREG melanoregulin
MSH6 mutS homolog 6
MSLN mesothelin
MUC16 mucin 16, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NBEA neurobeachin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK2 NIMA-related kinase 2
NNT nicotinamide nucleotide transhydrogenase
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
OBSL1 obscurin-like 1
OLFM4 olfactomedin 4
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PGM1 phosphoglucomutase 1
PLAT plasminogen activator, tissue
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTK2B protein tyrosine kinase 2 beta
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBP1 retinol binding protein 1, cellular
RFC3 replication factor C (activator 1) 3, 38kDa
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGN serglycin
STAR steroidogenic acute regulatory protein
STMN1 stathmin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGM2 transglutaminase 2
THAP11 THAP domain containing 11
THBS2 thrombospondin 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TMX4 thioredoxin-related transmembrane protein 4
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN12 tetraspanin 12
TSPAN8 tetraspanin 8
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VCAN versican
ZFPM2 zinc finger protein, FOG family member 2
ZWINT ZW10 interacting kinetochore protein