BRD-K88378636_withaferin-a_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

328 genes differentially expressed following the BRD-K88378636_withaferin-a_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ANGPTL2 angiopoietin-like 2
ARC activity-regulated cytoskeleton-associated protein
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ASRGL1 asparaginase like 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BTG2 BTG family, member 2
C1ORF56 chromosome 1 open reading frame 56
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCK cholecystokinin
CD14 CD14 molecule
CD163 CD163 molecule
CD200 CD200 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD69 CD69 molecule
CD83 CD83 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CREM cAMP responsive element modulator
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CUX2 cut-like homeobox 2
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN3 endothelin 3
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
EPHA4 EPH receptor A4
ETHE1 ethylmalonic encephalopathy 1
EXPH5 exophilin 5
FCGBP Fc fragment of IgG binding protein
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGL2 fibrinogen-like 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FMOD fibromodulin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF2 forkhead box F2
FRZB frizzled-related protein
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FXYD3 FXYD domain containing ion transport regulator 3
FXYD6 FXYD domain containing ion transport regulator 6
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GPER1 G protein-coupled estrogen receptor 1
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRASP1 G protein-coupled receptor associated sorting protein 1
HBB hemoglobin, beta
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA1 high mobility group AT-hook 1
HMOX1 heme oxygenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IRF6 interferon regulatory factor 6
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
JUNB jun B proto-oncogene
JUP junction plakoglobin
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LMO4 LIM domain only 4
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
LY6H lymphocyte antigen 6 complex, locus H
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MPZL2 myelin protein zero-like 2
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OLFML1 olfactomedin-like 1
OSBPL10 oxysterol binding protein-like 10
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH17 protocadherin 17
PDE2A phosphodiesterase 2A, cGMP-stimulated
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLVAP plasmalemma vesicle associated protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKX protein kinase, X-linked
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RNASET2 ribonuclease T2
RUNX3 runt-related transcription factor 3
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLPI secretory leukocyte peptidase inhibitor
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
SULF1 sulfatase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYK spleen tyrosine kinase
TERT telomerase reverse transcriptase
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBD thrombomodulin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TMEM35 transmembrane protein 35
TMEM70 transmembrane protein 70
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TRAF4 TNF receptor-associated factor 4
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
TRIM36 tripartite motif containing 36
TXNL4B thioredoxin-like 4B
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
XCL1 chemokine (C motif) ligand 1
ZBED2 zinc finger, BED-type containing 2
ZFP36 ZFP36 ring finger protein
ZIC1 Zic family member 1
ZNF331 zinc finger protein 331
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD2 abhydrolase domain containing 2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CALU calumenin
CCNG1 cyclin G1
CD164 CD164 molecule, sialomucin
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLINT1 clathrin interactor 1
COL5A1 collagen, type V, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DHCR24 24-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
ERO1L ERO1-like (S. cerevisiae)
FGFR3 fibroblast growth factor receptor 3
FLNA filamin A, alpha
FLNB filamin B, beta
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLIPR1 GLI pathogenesis-related 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GREM1 gremlin 1, DAN family BMP antagonist
HN1L hematological and neurological expressed 1-like
HOXA5 homeobox A5
HOXC6 homeobox C6
IL6ST interleukin 6 signal transducer
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF2C kinesin family member 2C
KLHL9 kelch-like family member 9
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NEK7 NIMA-related kinase 7
NFIB nuclear factor I/B
NNT nicotinamide nucleotide transhydrogenase
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
PALLD palladin, cytoskeletal associated protein
PDZK1IP1 PDZK1 interacting protein 1
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTX3 pentraxin 3, long
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC23A Sec23 homolog A (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGM2 transglutaminase 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNS1 tensin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
USP48 ubiquitin specific peptidase 48