BRD-K88378636_withaferin-a_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

289 genes differentially expressed following the BRD-K88378636_withaferin-a_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSS3 acyl-CoA synthetase short-chain family member 3
AKAP8L A kinase (PRKA) anchor protein 8-like
ALB albumin
ANKRD10 ankyrin repeat domain 10
ARG1 arginase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BCL2A1 BCL2-related protein A1
BLNK B-cell linker
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C5AR1 complement component 5a receptor 1
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD52 CD52 molecule
CD83 CD83 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CREM cAMP responsive element modulator
CSRP2 cysteine and glycine-rich protein 2
CTBS chitobiase, di-N-acetyl-
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
ELN elastin
EMP1 epithelial membrane protein 1
EZR ezrin
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FBXO11 F-box protein 11
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA2 GATA binding protein 2
GLRX glutaredoxin (thioltransferase)
GLRX2 glutaredoxin 2
GLUL glutamate-ammonia ligase
GOLT1B golgi transport 1B
GPRASP1 G protein-coupled receptor associated sorting protein 1
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI30 interferon, gamma-inducible protein 30
IFRD1 interferon-related developmental regulator 1
IFRD2 interferon-related developmental regulator 2
IGKV1-5 immunoglobulin kappa variable 1-5
IL10RA interleukin 10 receptor, alpha
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1E metallothionein 1E
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
NDFIP1 Nedd4 family interacting protein 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
OXSR1 oxidative stress responsive 1
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PLBD1 phospholipase B domain containing 1
PPARG peroxisome proliferator-activated receptor gamma
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
R3HDM4 R3H domain containing 4
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RNF103 ring finger protein 103
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SQLE squalene epoxidase
STK38L serine/threonine kinase 38 like
STXBP6 syntaxin binding protein 6 (amisyn)
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN13 tetraspanin 13
TSPYL2 TSPY-like 2
TUBB2A tubulin, beta 2A class IIa
TXNL4B thioredoxin-like 4B
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADAM10 ADAM metallopeptidase domain 10
ADAR adenosine deaminase, RNA-specific
ADGRG6 adhesion G protein-coupled receptor G6
AGTR1 angiotensin II receptor, type 1
AKR1C3 aldo-keto reductase family 1, member C3
AQP3 aquaporin 3 (Gill blood group)
ARHGAP1 Rho GTPase activating protein 1
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATMIN ATM interactor
AURKA aurora kinase A
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK19 cyclin-dependent kinase 19
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
COG4 component of oligomeric golgi complex 4
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP2 cellular retinoic acid binding protein 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTA cystatin A (stefin A)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPK1 death-associated protein kinase 1
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERMP1 endoplasmic reticulum metallopeptidase 1
FAM120A family with sequence similarity 120A
FGFR2 fibroblast growth factor receptor 2
FOXM1 forkhead box M1
FXYD2 FXYD domain containing ion transport regulator 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GLDC glycine dehydrogenase (decarboxylating)
HMG20B high mobility group 20B
HMGB3 high mobility group box 3
HOPX HOP homeobox
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
IFI44L interferon-induced protein 44-like
IGFBP6 insulin-like growth factor binding protein 6
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMA5 laminin, alpha 5
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LPCAT1 lysophosphatidylcholine acyltransferase 1
LY6E lymphocyte antigen 6 complex, locus E
LY75 lymphocyte antigen 75
LYPLA1 lysophospholipase I
MGP matrix Gla protein
MKL2 MKL/myocardin-like 2
MLEC malectin
MMP7 matrix metallopeptidase 7
MTUS1 microtubule associated tumor suppressor 1
MYOF myoferlin
NAV2 neuron navigator 2
NBN nibrin
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NOTCH2 notch 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDCD3 NudC domain containing 3
PBK PDZ binding kinase
PDZRN3 PDZ domain containing ring finger 3
PHKB phosphorylase kinase, beta
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PUF60 poly-U binding splicing factor 60KDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SCAND1 SCAN domain containing 1
SEPW1 selenoprotein W, 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRIM14 tripartite motif containing 14
TRIM16 tripartite motif containing 16
TUSC3 tumor suppressor candidate 3
VGLL1 vestigial-like family member 1
XPO1 exportin 1