BRD-K88378636_withaferin-a_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

383 genes differentially expressed following the BRD-K88378636_withaferin-a_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AQP9 aquaporin 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BMP7 bone morphogenetic protein 7
CARS cysteinyl-tRNA synthetase
CCND1 cyclin D1
CD9 CD9 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLPTM1 cleft lip and palate associated transmembrane protein 1
COBL cordon-bleu WH2 repeat protein
COL2A1 collagen, type II, alpha 1
COL6A2 collagen, type VI, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSG3 desmoglein 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR3 early growth response 3
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FRS2 fibroblast growth factor receptor substrate 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
H2BFS H2B histone family, member S (pseudogene)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IL11 interleukin 11
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO13 importin 13
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAD1 ladinin 1
LAMP3 lysosomal-associated membrane protein 3
LHFPL2 lipoma HMGIC fusion partner-like 2
LYRM1 LYR motif containing 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK13 mitogen-activated protein kinase 13
MAST2 microtubule associated serine/threonine kinase 2
MCOLN1 mucolipin 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1M metallothionein 1M
MX2 MX dynamin-like GTPase 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NBPF10 neuroblastoma breakpoint family, member 10
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPC1 Niemann-Pick disease, type C1
NR1H2 nuclear receptor subfamily 1, group H, member 2
OASL 2'-5'-oligoadenylate synthetase-like
ODC1 ornithine decarboxylase 1
OLFML2B olfactomedin-like 2B
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE4DIP phosphodiesterase 4D interacting protein
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PODXL podocalyxin-like
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PRSS21 protease, serine, 21 (testisin)
RBKS ribokinase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS3 regulator of G-protein signaling 3
RIN3 Ras and Rab interactor 3
RND3 Rho family GTPase 3
RUNX3 runt-related transcription factor 3
RYBP RING1 and YY1 binding protein
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC16A6 solute carrier family 16, member 6
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
STK10 serine/threonine kinase 10
SYNM synemin, intermediate filament protein
TEX10 testis expressed 10
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPRSS3 transmembrane protease, serine 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANOS1 anosmin 1
ANXA4 annexin A4
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BAD BCL2-associated agonist of cell death
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
C1RL complement component 1, r subcomponent-like
C3 complement component 3
C5 complement component 5
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV2 caveolin 2
CCNA2 cyclin A2
CD24 CD24 molecule
CD52 CD52 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
CDK14 cyclin-dependent kinase 14
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFH complement factor H
CFI complement factor I
CKLF chemokine-like factor
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CTSC cathepsin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DHFR dihydrofolate reductase
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
ETV1 ets variant 1
F12 coagulation factor XII (Hageman factor)
F2R coagulation factor II (thrombin) receptor
FBXO5 F-box protein 5
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FZD5 frizzled class receptor 5
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GCHFR GTP cyclohydrolase I feedback regulator
GCLC glutamate-cysteine ligase, catalytic subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
HMGN3 high mobility group nucleosomal binding domain 3
HNMT histamine N-methyltransferase
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IPO5 importin 5
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KCTD3 potassium channel tetramerization domain containing 3
KIF11 kinesin family member 11
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRRC17 leucine rich repeat containing 17
LUM lumican
LXN latexin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGED1 melanoma antigen family D1
MANSC1 MANSC domain containing 1
MARCKSL1 MARCKS-like 1
MBP myelin basic protein
MEGF9 multiple EGF-like-domains 9
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYH10 myosin, heavy chain 10, non-muscle
NAV2 neuron navigator 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK2 NIMA-related kinase 2
NLGN4X neuroligin 4, X-linked
NLRP2 NLR family, pyrin domain containing 2
NOVA1 neuro-oncological ventral antigen 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
NSG1 neuron specific gene family member 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OPN3 opsin 3
PAIP1 poly(A) binding protein interacting protein 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PGD phosphogluconate dehydrogenase
PGM1 phosphoglucomutase 1
PLA1A phospholipase A1 member A
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLSCR4 phospholipid scramblase 4
PNMA2 paraneoplastic Ma antigen 2
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PON2 paraoxonase 2
PON3 paraoxonase 3
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM3 RNA binding motif (RNP1, RRM) protein 3
RECQL RecQ helicase-like
RFC3 replication factor C (activator 1) 3, 38kDa
RGCC regulator of cell cycle
RNASE4 ribonuclease, RNase A family, 4
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SEC23A Sec23 homolog A (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC16A4 solute carrier family 16, member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC1A structural maintenance of chromosomes 1A
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTSSA serine palmitoyltransferase, small subunit A
SRI sorcin
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN1 stathmin 1
STS steroid sulfatase (microsomal), isozyme S
SUB1 SUB1 homolog (S. cerevisiae)
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TF transferrin
TFAM transcription factor A, mitochondrial
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMED5 transmembrane emp24 protein transport domain containing 5
TMEM47 transmembrane protein 47
TMX4 thioredoxin-related transmembrane protein 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TRMT5 tRNA methyltransferase 5
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TSPAN6 tetraspanin 6
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18