BRD-K88378636_withaferin-a_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

235 genes differentially expressed following the BRD-K88378636_withaferin-a_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAT1 adenosine deaminase, tRNA-specific 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
APOD apolipoprotein D
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CD83 CD83 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN2AIP CDKN2A interacting protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COL1A1 collagen, type I, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CRISP3 cysteine-rich secretory protein 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYR61 cysteine-rich, angiogenic inducer, 61
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRY furry homolog (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
H2BFS H2B histone family, member S (pseudogene)
HDAC9 histone deacetylase 9
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6 interleukin 6
ING3 inhibitor of growth family, member 3
IRF8 interferon regulatory factor 8
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LOC100505650 uncharacterized LOC100505650
LRMP lymphoid-restricted membrane protein
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK13 mitogen-activated protein kinase 13
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
OSR2 odd-skipped related transciption factor 2
PADI2 peptidyl arginine deiminase, type II
PDGFRL platelet-derived growth factor receptor-like
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBM25 RNA binding motif protein 25
RGS10 regulator of G-protein signaling 10
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND3 Rho family GTPase 3
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAP18 Sin3A-associated protein, 18kDa
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SMIM7 small integral membrane protein 7
SPATS2L spermatogenesis associated, serine-rich 2-like
SPDEF SAM pointed domain containing ETS transcription factor
SRSF7 serine/arginine-rich splicing factor 7
ST7 suppression of tumorigenicity 7
STC1 stanniocalcin 1
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2B transformer 2 beta homolog (Drosophila)
TRIM36 tripartite motif containing 36
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPH aspartate beta-hydroxylase
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
C1ORF116 chromosome 1 open reading frame 116
CA12 carbonic anhydrase XII
CA9 carbonic anhydrase IX
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
COPA coatomer protein complex, subunit alpha
DPYSL2 dihydropyrimidinase-like 2
DRAM1 DNA-damage regulated autophagy modulator 1
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
EXOSC4 exosome component 4
FZD6 frizzled class receptor 6
GDE1 glycerophosphodiester phosphodiesterase 1
GPSM2 G-protein signaling modulator 2
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOPX HOP homeobox
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IL13RA2 interleukin 13 receptor, alpha 2
JAG1 jagged 1
KLHL9 kelch-like family member 9
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
LYPLA1 lysophospholipase I
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MGP matrix Gla protein
MN1 meningioma (disrupted in balanced translocation) 1
MSRB2 methionine sulfoxide reductase B2
NIT1 nitrilase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
PANK3 pantothenate kinase 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POSTN periostin, osteoblast specific factor
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSPH phosphoserine phosphatase
PUF60 poly-U binding splicing factor 60KDa
RAB13 RAB13, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
SCAND1 SCAN domain containing 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A46 solute carrier family 25, member 46
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPON1 spondin 1, extracellular matrix protein
SVIL supervillin
TLR4 toll-like receptor 4
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMX4 thioredoxin-related transmembrane protein 4
TNS1 tensin 1
TNS3 tensin 3
TSPAN6 tetraspanin 6
USP6NL USP6 N-terminal like
VCAN versican
WWTR1 WW domain containing transcription regulator 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18