BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL2A1 collagen, type II, alpha 1
COMP cartilage oligomeric matrix protein
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EIF5A eukaryotic translation initiation factor 5A
ELN elastin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
GSTA4 glutathione S-transferase alpha 4
HMOX1 heme oxygenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ITGB5 integrin, beta 5
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KYNU kynureninase
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIA melanoma inhibitory activity
MTUS1 microtubule associated tumor suppressor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFML2B olfactomedin-like 2B
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
SCRG1 stimulator of chondrogenesis 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AKAP12 A kinase (PRKA) anchor protein 12
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
B3GNT1
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLEC11A C-type lectin domain family 11, member A
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DKK3 dickkopf WNT signaling pathway inhibitor 3
ENO2 enolase 2 (gamma, neuronal)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FILIP1L filamin A interacting protein 1-like
FOLR1 folate receptor 1 (adult)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXA10 homeobox A10
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL17RB interleukin 17 receptor B
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAMA3 laminin, alpha 3
LOC100505650 uncharacterized LOC100505650
MME membrane metallo-endopeptidase
MSLN mesothelin
NREP neuronal regeneration related protein
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PDGFC platelet derived growth factor C
PHLDA2 pleckstrin homology-like domain, family A, member 2
RAB4A RAB4A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCAN2 regulator of calcineurin 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
ST7 suppression of tumorigenicity 7
STK39 serine threonine kinase 39
TACSTD2 tumor-associated calcium signal transducer 2
TNNT1 troponin T type 1 (skeletal, slow)
TUBA1A tubulin, alpha 1a
VIM vimentin
WFDC2 WAP four-disulfide core domain 2
ZBED2 zinc finger, BED-type containing 2