BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACVR1 activin A receptor, type I
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
CD52 CD52 molecule
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DST dystonin
FAM110B family with sequence similarity 110, member B
FGFR1 fibroblast growth factor receptor 1
GCLC glutamate-cysteine ligase, catalytic subunit
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGKV1-5 immunoglobulin kappa variable 1-5
IL32 interleukin 32
ITM2A integral membrane protein 2A
JAM3 junctional adhesion molecule 3
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
MBP myelin basic protein
MCOLN1 mucolipin 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLBD1 phospholipase B domain containing 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
S100A9 S100 calcium binding protein A9
SFN stratifin
SPRED2 sprouty-related, EVH1 domain containing 2
SQSTM1 sequestosome 1
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK AHNAK nucleoprotein
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
C1ORF116 chromosome 1 open reading frame 116
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCND1 cyclin D1
COL5A2 collagen, type V, alpha 2
CTSH cathepsin H
DPYSL3 dihydropyrimidinase-like 3
ECD ecdysoneless homolog (Drosophila)
FLNA filamin A, alpha
GNAS GNAS complex locus
GOLGA8H golgin A8 family, member H
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IL1B interleukin 1, beta
IRS2 insulin receptor substrate 2
KRT7 keratin 7, type II
MAPT microtubule-associated protein tau
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
NRP1 neuropilin 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PNISR PNN-interacting serine/arginine-rich protein
PRPS1 phosphoribosyl pyrophosphate synthetase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor