BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADM adrenomedullin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL6A1 collagen, type VI, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DIO2 deiodinase, iodothyronine, type II
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGKV4-1 immunoglobulin kappa variable 4-1
IL1R2 interleukin 1 receptor, type II
JMJD6 jumonji domain containing 6
KLF4 Kruppel-like factor 4 (gut)
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LHFPL2 lipoma HMGIC fusion partner-like 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
NAMPT nicotinamide phosphoribosyltransferase
NOTCH3 notch 3
NRCAM neuronal cell adhesion molecule
PBX1 pre-B-cell leukemia homeobox 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PIR pirin (iron-binding nuclear protein)
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PKP1 plakophilin 1
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
THBD thrombomodulin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNPO1 transportin 1
TUBB2A tubulin, beta 2A class IIa
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VWF von Willebrand factor
WISP2 WNT1 inducible signaling pathway protein 2
XBP1 X-box binding protein 1

decreased expression

Symbol Name
B3GNT1
C14ORF159 chromosome 14 open reading frame 159
CCNB2 cyclin B2
CD24 CD24 molecule
CYR61 cysteine-rich, angiogenic inducer, 61
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA10 homeobox A10
JADE2 jade family PHD finger 2
LUM lumican
MSL1 male-specific lethal 1 homolog (Drosophila)
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
RGS13 regulator of G-protein signaling 13
SHANK2 SH3 and multiple ankyrin repeat domains 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNS3 tensin 3
TXNL4A thioredoxin-like 4A
VCAN versican
VSNL1 visinin-like 1