BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

201 genes differentially expressed following the BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACLY ATP citrate lyase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALAS1 5'-aminolevulinate synthase 1
AMDHD2 amidohydrolase domain containing 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
CA2 carbonic anhydrase II
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD163 CD163 molecule
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA2 chloride channel accessory 2
CLCN3 chloride channel, voltage-sensitive 3
CLGN calmegin
CRISP3 cysteine-rich secretory protein 3
CTSL cathepsin L
DEFA5 defensin, alpha 5, Paneth cell-specific
DENND1B DENN/MADD domain containing 1B
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOSL1 FOS-like antigen 1
GALE UDP-galactose-4-epimerase
GCLC glutamate-cysteine ligase, catalytic subunit
GPR137B G protein-coupled receptor 137B
HMOX1 heme oxygenase 1
IL13RA2 interleukin 13 receptor, alpha 2
KYNU kynureninase
LEPROT leptin receptor overlapping transcript
MAN1A1 mannosidase, alpha, class 1A, member 1
MCOLN1 mucolipin 1
MICALL1 MICAL-like 1
NELL2 NEL-like 2 (chicken)
NTS neurotensin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PRF1 perforin 1 (pore forming protein)
RBMS1 RNA binding motif, single stranded interacting protein 1
RYBP RING1 and YY1 binding protein
SATB2 SATB homeobox 2
SLC16A6 solute carrier family 16, member 6
SMTN smoothelin
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STEAP3 STEAP family member 3, metalloreductase
STXBP1 syntaxin binding protein 1
THBD thrombomodulin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNPO1 transportin 1
TSPAN4 tetraspanin 4
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
WNT5A wingless-type MMTV integration site family, member 5A
WNT5B wingless-type MMTV integration site family, member 5B
WWP1 WW domain containing E3 ubiquitin protein ligase 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACOT9 acyl-CoA thioesterase 9
ANXA3 annexin A3
ANXA6 annexin A6
ARL3 ADP-ribosylation factor-like 3
ARMCX1 armadillo repeat containing, X-linked 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BHLHE40 basic helix-loop-helix family, member e40
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
C7 complement component 7
CALB1 calbindin 1, 28kDa
CALD1 caldesmon 1
CCDC85B coiled-coil domain containing 85B
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNG1 cyclin G1
CCNI cyclin I
CD200 CD200 molecule
CD24 CD24 molecule
CD58 CD58 molecule
CD81 CD81 molecule
CDC42 cell division cycle 42
CFLAR CASP8 and FADD-like apoptosis regulator
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPE carboxypeptidase E
CTSH cathepsin H
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYTH1 cytohesin 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPT dermatopontin
DSTN destrin (actin depolymerizing factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM13A family with sequence similarity 13, member A
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBP1 guanylate binding protein 1, interferon-inducible
GPX3 glutathione peroxidase 3
GPX7 glutathione peroxidase 7
HLA-B major histocompatibility complex, class I, B
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB6 homeobox B6
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
KLF9 Kruppel-like factor 9
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LITAF lipopolysaccharide-induced TNF factor
LMCD1 LIM and cysteine-rich domains 1
LOXL1 lysyl oxidase-like 1
LYZ lysozyme
MAGED1 melanoma antigen family D1
MAGEH1 melanoma antigen family H1
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MPO myeloperoxidase
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
PBX1 pre-B-cell leukemia homeobox 1
PDLIM1 PDZ and LIM domain 1
PEBP1 phosphatidylethanolamine binding protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLN phospholamban
PRDX4 peroxiredoxin 4
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGIS prostaglandin I2 (prostacyclin) synthase
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RPS11 ribosomal protein S11
SCRG1 stimulator of chondrogenesis 1
SELE selectin E
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIAH2 siah E3 ubiquitin protein ligase 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNN stannin
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SRGN serglycin
SUB1 SUB1 homolog (S. cerevisiae)
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNIP1 TNFAIP3 interacting protein 1
TSPYL4 TSPY-like 4
UBE2J1 ubiquitin-conjugating enzyme E2, J1
XBP1 X-box binding protein 1
ZMIZ1 zinc finger, MIZ-type containing 1