BRD-K87947369_VX-680_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K87947369_VX-680_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
AURKA aurora kinase A
CD163 CD163 molecule
CIT citron rho-interacting serine/threonine kinase
CRABP2 cellular retinoic acid binding protein 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DPYSL3 dihydropyrimidinase-like 3
ECI1 enoyl-CoA delta isomerase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOXM1 forkhead box M1
FXR1 fragile X mental retardation, autosomal homolog 1
GLUL glutamate-ammonia ligase
HMMR hyaluronan-mediated motility receptor (RHAMM)
KDM3A lysine (K)-specific demethylase 3A
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LMO3 LIM domain only 3 (rhombotin-like 2)
LYPD1 LY6/PLAUR domain containing 1
NARF nuclear prelamin A recognition factor
NCAPD2 non-SMC condensin I complex, subunit D2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
RAD21 RAD21 homolog (S. pombe)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
TBL1X transducin (beta)-like 1X-linked
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TKT transketolase
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TTK TTK protein kinase
TYROBP TYRO protein tyrosine kinase binding protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
YBX3 Y box binding protein 3

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM19 ADAM metallopeptidase domain 19
BZW1 basic leucine zipper and W2 domains 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
COL6A1 collagen, type VI, alpha 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GCH1 GTP cyclohydrolase 1
GCLC glutamate-cysteine ligase, catalytic subunit
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HSPH1 heat shock 105kDa/110kDa protein 1
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KRT17 keratin 17, type I
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SEPP1 selenoprotein P, plasma, 1
SIK1 salt-inducible kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TNC tenascin C
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing