BRD-K87909389_alvocidib_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

244 genes differentially expressed following the BRD-K87909389_alvocidib_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACOT13 acyl-CoA thioesterase 13
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
AHSG alpha-2-HS-glycoprotein
AIF1 allograft inflammatory factor 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD36B ankyrin repeat domain 36B
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOA2 apolipoprotein A-II
APOB apolipoprotein B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AUTS2 autism susceptibility candidate 2
BAG2 BCL2-associated athanogene 2
BID BH3 interacting domain death agonist
CADM1 cell adhesion molecule 1
CAPG capping protein (actin filament), gelsolin-like
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD3D CD3d molecule, delta (CD3-TCR complex)
CELF2 CUGBP, Elav-like family member 2
CEP70 centrosomal protein 70kDa
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
COLEC12 collectin sub-family member 12
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSV cathepsin V
CYBA cytochrome b-245, alpha polypeptide
DEPTOR DEP domain containing MTOR-interacting protein
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FAM8A1 family with sequence similarity 8, member A1
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXC1 forkhead box C1
FST follistatin
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPC3 glypican 3
GPX3 glutathione peroxidase 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HP haptoglobin
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IL2RG interleukin 2 receptor, gamma
IRS1 insulin receptor substrate 1
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KLF9 Kruppel-like factor 9
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
MAN2A1 mannosidase, alpha, class 2A, member 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCFD2 multiple coagulation factor deficiency 2
MEF2C myocyte enhancer factor 2C
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MSN moesin
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM1 olfactomedin 1
OSMR oncostatin M receptor
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDLIM1 PDZ and LIM domain 1
PER1 period circadian clock 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLS1 plastin 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PVALB parvalbumin
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC1A structural maintenance of chromosomes 1A
SOCS2 suppressor of cytokine signaling 2
SRPR signal recognition particle receptor (docking protein)
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
THBS4 thrombospondin 4
TLE2 transducin-like enhancer of split 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
TRBC1 T cell receptor beta constant 1
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
VWA5A von Willebrand factor A domain containing 5A
WFDC2 WAP four-disulfide core domain 2
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZIC1 Zic family member 1
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BLCAP bladder cancer associated protein
BLMH bleomycin hydrolase
C2CD5 C2 calcium-dependent domain containing 5
CA2 carbonic anhydrase II
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CASC3 cancer susceptibility candidate 3
CCDC47 coiled-coil domain containing 47
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CKS1B CDC28 protein kinase regulatory subunit 1B
CLGN calmegin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
GCH1 GTP cyclohydrolase 1
GDI2 GDP dissociation inhibitor 2
GPX2 glutathione peroxidase 2
H2AFZ H2A histone family, member Z
HK1 hexokinase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
INHBB inhibin, beta B
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LBR lamin B receptor
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAGEA3 melanoma antigen family A3
MALT1 MALT1 paracaspase
MED24 mediator complex subunit 24
MMP11 matrix metallopeptidase 11
MSL1 male-specific lethal 1 homolog (Drosophila)
MSMB microseminoprotein, beta-
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NET1 neuroepithelial cell transforming 1
NKX3-1 NK3 homeobox 1
NPY1R neuropeptide Y receptor Y1
OPN3 opsin 3
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PNP purine nucleoside phosphorylase
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RIN2 Ras and Rab interactor 2
RNPS1 RNA binding protein S1, serine-rich domain
RPL22 ribosomal protein L22
RPS4Y1 ribosomal protein S4, Y-linked 1
RRBP1 ribosome binding protein 1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
RYBP RING1 and YY1 binding protein
SCAND1 SCAN domain containing 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF5 serine/arginine-rich splicing factor 5
ST7 suppression of tumorigenicity 7
STAU1 staufen double-stranded RNA binding protein 1
TDO2 tryptophan 2,3-dioxygenase
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM9SF3 transmembrane 9 superfamily member 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB3 tribbles pseudokinase 3
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2I ubiquitin-conjugating enzyme E2I
UBE3C ubiquitin protein ligase E3C
USP22 ubiquitin specific peptidase 22
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF217 zinc finger protein 217
ZWINT ZW10 interacting kinetochore protein