BRD-K87909389_alvocidib_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K87909389_alvocidib_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATF3 activating transcription factor 3
BACE2 beta-site APP-cleaving enzyme 2
BSG basigin (Ok blood group)
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CD320 CD320 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD48 CD48 molecule
CETN2 centrin, EF-hand protein, 2
CFH complement factor H
CKLF chemokine-like factor
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CSF1R colony stimulating factor 1 receptor
CSTA cystatin A (stefin A)
CTTN cortactin
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOXO4 forkhead box O4
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HCAR3 hydroxycarboxylic acid receptor 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
LAMP3 lysosomal-associated membrane protein 3
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
PALLD palladin, cytoskeletal associated protein
PLAT plasminogen activator, tissue
PLVAP plasmalemma vesicle associated protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
SCG2 secretogranin II
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
SSPN sarcospan
TFPI2 tissue factor pathway inhibitor 2
THY1 Thy-1 cell surface antigen
TNS1 tensin 1
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
VWF von Willebrand factor
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARF6 ADP-ribosylation factor 6
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP55 centrosomal protein 55kDa
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
DUSP6 dual specificity phosphatase 6
FBL fibrillarin
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
HMGB2 high mobility group box 2
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSPA8 heat shock 70kDa protein 8
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KLF4 Kruppel-like factor 4 (gut)
LASP1 LIM and SH3 protein 1
LMNB1 lamin B1
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKI67 marker of proliferation Ki-67
MTCL1 microtubule crosslinking factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYO10 myosin X
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RNPS1 RNA binding protein S1, serine-rich domain
S100A7 S100 calcium binding protein A7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD3 SMAD family member 3
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
TACC2 transforming, acidic coiled-coil containing protein 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
XPO7 exportin 7
YBX3 Y box binding protein 3