BRD-K87909389_alvocidib_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

223 genes differentially expressed following the BRD-K87909389_alvocidib_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AIF1 allograft inflammatory factor 1
ANKRD36B ankyrin repeat domain 36B
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BACE2 beta-site APP-cleaving enzyme 2
BLNK B-cell linker
BSG basigin (Ok blood group)
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CERS6 ceramide synthase 6
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CTBS chitobiase, di-N-acetyl-
CTGF connective tissue growth factor
CTSC cathepsin C
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DYNLT3 dynein, light chain, Tctex-type 3
ECHDC2 enoyl CoA hydratase domain containing 2
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
ENO1 enolase 1, (alpha)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM162A family with sequence similarity 162, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
GAS6 growth arrest-specific 6
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSAP gamma-secretase activating protein
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
IDS iduronate 2-sulfatase
IGFBP3 insulin-like growth factor binding protein 3
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP1 latent transforming growth factor beta binding protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MBP myelin basic protein
MEIS1 Meis homeobox 1
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYLK myosin light chain kinase
MYO6 myosin VI
NME1 NME/NM23 nucleoside diphosphate kinase 1
NREP neuronal regeneration related protein
OSBPL1A oxysterol binding protein-like 1A
PBX3 pre-B-cell leukemia homeobox 3
PECR peroxisomal trans-2-enoyl-CoA reductase
PEG3 paternally expressed 3
PLVAP plasmalemma vesicle associated protein
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRDX4 peroxiredoxin 4
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCP2 sterol carrier protein 2
SDC2 syndecan 2
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMYD3 SET and MYND domain containing 3
SOCS2 suppressor of cytokine signaling 2
SRPR signal recognition particle receptor (docking protein)
SSR1 signal sequence receptor, alpha
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SSR4 signal sequence receptor, delta
STC1 stanniocalcin 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM14B transmembrane protein 14B
TMEM259 transmembrane protein 259
TMEM45A transmembrane protein 45A
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATMIN ATM interactor
AURKA aurora kinase A
BLCAP bladder cancer associated protein
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAB39 calcium binding protein 39
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CHERP calcium homeostasis endoplasmic reticulum protein
CLTA clathrin, light chain A
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSNK1D casein kinase 1, delta
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPSM2 G-protein signaling modulator 2
GPX2 glutathione peroxidase 2
H2AFX H2A histone family, member X
HMMR hyaluronan-mediated motility receptor (RHAMM)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LBR lamin B receptor
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MICALL1 MICAL-like 1
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NUSAP1 nucleolar and spindle associated protein 1
OLFM4 olfactomedin 4
PDE4B phosphodiesterase 4B, cAMP-specific
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PUF60 poly-U binding splicing factor 60KDa
PUM1 pumilio RNA-binding family member 1
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF114 ring finger protein 114
RNPS1 RNA binding protein S1, serine-rich domain
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC38A2 solute carrier family 38, member 2
SMC4 structural maintenance of chromosomes 4
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNRG synergin, gamma
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPYL5 TSPY-like 5
TTK TTK protein kinase
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF217 zinc finger protein 217