BRD-K86856088_UNC0638_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K86856088_UNC0638_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACVR1B activin A receptor, type IB
AGR2 anterior gradient 2
ANKMY2 ankyrin repeat and MYND domain containing 2
ARMCX1 armadillo repeat containing, X-linked 1
ASCL1 achaete-scute family bHLH transcription factor 1
BZW2 basic leucine zipper and W2 domains 2
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CD24 CD24 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL9A2 collagen, type IX, alpha 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
EHF ets homologous factor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGSF3 immunoglobulin superfamily, member 3
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LDLR low density lipoprotein receptor
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LPIN1 lipin 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MTA1 metastasis associated 1
MTSS1 metastasis suppressor 1
MVP major vault protein
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
OXA1L oxidase (cytochrome c) assembly 1-like
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLK2 polo-like kinase 2
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RAP1GAP RAP1 GTPase activating protein
RNASE4 ribonuclease, RNase A family, 4
SKAP2 src kinase associated phosphoprotein 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STXBP1 syntaxin binding protein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMC5 transmembrane channel-like 5
TOX3 TOX high mobility group box family member 3
TSPAN13 tetraspanin 13
VIM vimentin

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
AUTS2 autism susceptibility candidate 2
CBR1 carbonyl reductase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A1 collagen, type I, alpha 1
CORO1A coronin, actin binding protein, 1A
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS2 dehydrogenase/reductase (SDR family) member 2
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HP haptoglobin
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGHM immunoglobulin heavy constant mu
LEF1 lymphoid enhancer-binding factor 1
LPAR1 lysophosphatidic acid receptor 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
NHP2 NHP2 ribonucleoprotein
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM1 PDZ and LIM domain 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRKCB protein kinase C, beta
RBP1 retinol binding protein 1, cellular
SLN sarcolipin
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR3 small proline-rich protein 3
STC2 stanniocalcin 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TCL1A T-cell leukemia/lymphoma 1A
TRBC1 T cell receptor beta constant 1
URI1 URI1, prefoldin-like chaperone
YME1L1 YME1-like 1 ATPase