BRD-K86574132_-666_HEPG2_6.0_h_48.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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73 genes differentially expressed following the BRD-K86574132_-666_HEPG2_6.0_h_48.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
ATF3 activating transcription factor 3
CA12 carbonic anhydrase XII
CCL8 chemokine (C-C motif) ligand 8
CD38 CD38 molecule
CLIC4 chloride intracellular channel 4
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GBP1 guanylate binding protein 1, interferon-inducible
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
IER3 immediate early response 3
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTS neurotensin
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A8 S100 calcium binding protein A8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRSF6 serine/arginine-rich splicing factor 6
SYNE2 spectrin repeat containing, nuclear envelope 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSC22D1 TSC22 domain family, member 1
TXN thioredoxin
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
ATF5 activating transcription factor 5
CCNB1 cyclin B1
CPB1 carboxypeptidase B1 (tissue)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF5 eukaryotic translation initiation factor 5
EXT1 exostosin glycosyltransferase 1
FBLN1 fibulin 1
FN1 fibronectin 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LITAF lipopolysaccharide-induced TNF factor
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MEIS1 Meis homeobox 1
MSLN mesothelin
MT1E metallothionein 1E
MYH10 myosin, heavy chain 10, non-muscle
NEFH neurofilament, heavy polypeptide
PBX3 pre-B-cell leukemia homeobox 3
PDGFC platelet derived growth factor C
RRM2 ribonucleotide reductase M2
SDC4 syndecan 4
UBE3C ubiquitin protein ligase E3C