BRD-K86492010_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K86492010_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATF3 activating transcription factor 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CD9 CD9 molecule
CD93 CD93 molecule
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBXO11 F-box protein 11
G0S2 G0/G1 switch 2
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
LAMB3 laminin, beta 3
LRP12 low density lipoprotein receptor-related protein 12
MAP1B microtubule-associated protein 1B
MATN2 matrilin 2
MMP2 matrix metallopeptidase 2
MPPED2 metallophosphoesterase domain containing 2
MSLN mesothelin
MT1X metallothionein 1X
PKP2 plakophilin 2
PNMA2 paraneoplastic Ma antigen 2
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRKCI protein kinase C, iota
RBP1 retinol binding protein 1, cellular
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SNX7 sorting nexin 7
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
TCEAL2 transcription elongation factor A (SII)-like 2
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM176B transmembrane protein 176B
TUBB2B tubulin, beta 2B class IIb
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMD1 adenosylmethionine decarboxylase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BCLAF1 BCL2-associated transcription factor 1
C14ORF1 chromosome 14 open reading frame 1
CLU clusterin
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
FBLN5 fibulin 5
FGF13 fibroblast growth factor 13
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44L interferon-induced protein 44-like
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAMLD1 mastermind-like domain containing 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PXMP2 peroxisomal membrane protein 2, 22kDa
S100A7 S100 calcium binding protein A7
SC5D sterol-C5-desaturase
SELL selectin L
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORD sorbitol dehydrogenase
STAT1 signal transducer and activator of transcription 1, 91kDa
TARP TCR gamma alternate reading frame protein
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TLR4 toll-like receptor 4