BRD-K86456986_5,7-difluoro-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one KLK-46_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

33 genes differentially expressed following the BRD-K86456986_5,7-difluoro-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one KLK-46_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANGPT2 angiopoietin 2
AURKB aurora kinase B
CORO1A coronin, actin binding protein, 1A
CX3CR1 chemokine (C-X3-C motif) receptor 1
DLK1 delta-like 1 homolog (Drosophila)
EDN1 endothelin 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
KCTD12 potassium channel tetramerization domain containing 12
LOC100505650 uncharacterized LOC100505650
MARCKS myristoylated alanine-rich protein kinase C substrate
MUC16 mucin 16, cell surface associated
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
SCG2 secretogranin II

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CHPT1 choline phosphotransferase 1
CPM carboxypeptidase M
DRAM1 DNA-damage regulated autophagy modulator 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GLRX glutaredoxin (thioltransferase)
KRT18 keratin 18, type I
MSMB microseminoprotein, beta-
PCCB propionyl CoA carboxylase, beta polypeptide
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STOM stomatin
VDAC1 voltage-dependent anion channel 1