BRD-K86456986_5,7-difluoro-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one KLK-46_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

50 genes differentially expressed following the BRD-K86456986_5,7-difluoro-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one KLK-46_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCNG2 cyclin G2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
GMPR guanosine monophosphate reductase
IFI6 interferon, alpha-inducible protein 6
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LDOC1 leucine zipper, down-regulated in cancer 1
NOTCH2NL notch 2 N-terminal like
RBP4 retinol binding protein 4, plasma
SCUBE2 signal peptide, CUB domain, EGF-like 2
STC2 stanniocalcin 2
TBL1X transducin (beta)-like 1X-linked
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TRPS1 trichorhinophalangeal syndrome I
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1
XYLT1 xylosyltransferase I
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
CALB1 calbindin 1, 28kDa
CANX calnexin
CLTC clathrin, heavy chain (Hc)
CTSH cathepsin H
CXCL8 chemokine (C-X-C motif) ligand 8
DST dystonin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FASTKD5 FAST kinase domains 5
GPRC5A G protein-coupled receptor, class C, group 5, member A
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IPO5 importin 5
MSH6 mutS homolog 6
PGK1 phosphoglycerate kinase 1
PSPH phosphoserine phosphatase
S100A7 S100 calcium binding protein A7
SFRP1 secreted frizzled-related protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
TMEM47 transmembrane protein 47
UBE2A ubiquitin-conjugating enzyme E2A