BRD-K86231656_tert-butyl 4-(benzo[d]thiazol-2-yl)phenyl(methyl)carbamate GSuz-2_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K86231656_tert-butyl 4-(benzo[d]thiazol-2-yl)phenyl(methyl)carbamate GSuz-2_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ACADVL acyl-CoA dehydrogenase, very long chain
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BAX BCL2-associated X protein
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DNMBP dynamin binding protein
EMP1 epithelial membrane protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FCGBP Fc fragment of IgG binding protein
FDXR ferredoxin reductase
FOSL1 FOS-like antigen 1
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GPX2 glutathione peroxidase 2
HOXA10 homeobox A10
INTS3 integrator complex subunit 3
JAG1 jagged 1
LY6D lymphocyte antigen 6 complex, locus D
MARCKSL1 MARCKS-like 1
MX2 MX dynamin-like GTPase 2
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NID1 nidogen 1
OLFM4 olfactomedin 4
PGLS 6-phosphogluconolactonase
PIR pirin (iron-binding nuclear protein)
PMEPA1 prostate transmembrane protein, androgen induced 1
RAP1GAP RAP1 GTPase activating protein
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SRPX sushi-repeat containing protein, X-linked
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TP53I3 tumor protein p53 inducible protein 3
TRIM16 tripartite motif containing 16
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
VIM vimentin
WDR45 WD repeat domain 45
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATAD2 ATPase family, AAA domain containing 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CALU calumenin
CCNA2 cyclin A2
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPP4 dipeptidyl-peptidase 4
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
KIF14 kinesin family member 14
KIF23 kinesin family member 23
KRT23 keratin 23, type I
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSRA methionine sulfoxide reductase A
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAP2C RAP2C, member of RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
SFRP1 secreted frizzled-related protein 1
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TSPAN13 tetraspanin 13