BRD-K86027709_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K86027709_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACP5 acid phosphatase 5, tartrate resistant
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
AQP1 aquaporin 1 (Colton blood group)
BAD BCL2-associated agonist of cell death
BLNK B-cell linker
CD14 CD14 molecule
CD200 CD200 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLU clusterin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSH cathepsin H
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
DPYSL2 dihydropyrimidinase-like 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
GPX2 glutathione peroxidase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
IRF8 interferon regulatory factor 8
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LXN latexin
MAMLD1 mastermind-like domain containing 1
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCP4 Purkinje cell protein 4
PLXNC1 plexin C1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
SULF1 sulfatase 1
TM4SF1 transmembrane 4 L six family member 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
CA2 carbonic anhydrase II
CCNE2 cyclin E2
CLNS1A chloride channel, nucleotide-sensitive, 1A
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPN2 epsin 2
FAM57A family with sequence similarity 57, member A
FSTL1 follistatin-like 1
GLIPR1 GLI pathogenesis-related 1
GSPT2 G1 to S phase transition 2
GYS1 glycogen synthase 1 (muscle)
HINT1 histidine triad nucleotide binding protein 1
JMJD6 jumonji domain containing 6
LHX2 LIM homeobox 2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYPLA1 lysophospholipase I
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRDX2 peroxiredoxin 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RREB1 ras responsive element binding protein 1
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SMYD2 SET and MYND domain containing 2
STK17A serine/threonine kinase 17a
TPM4 tropomyosin 4
TRIB2 tribbles pseudokinase 2
TYRP1 tyrosinase-related protein 1