BRD-K85606544_neratinib_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K85606544_neratinib_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADAM10 ADAM metallopeptidase domain 10
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BEX1 brain expressed, X-linked 1
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCDC92 coiled-coil domain containing 92
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM129A family with sequence similarity 129, member A
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GPX1 glutathione peroxidase 1
GRB10 growth factor receptor-bound protein 10
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
JAG1 jagged 1
LMO4 LIM domain only 4
LXN latexin
MICALL1 MICAL-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NARS asparaginyl-tRNA synthetase
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
RAB13 RAB13, member RAS oncogene family
RPS11 ribosomal protein S11
SARS seryl-tRNA synthetase
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOCS2 suppressor of cytokine signaling 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK10 serine/threonine kinase 10
SVIL supervillin
TARS threonyl-tRNA synthetase
TCEA1 transcription elongation factor A (SII), 1
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
XPOT exportin, tRNA
XYLT1 xylosyltransferase I
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACLY ATP citrate lyase
ADCK3 aarF domain containing kinase 3
ADRB2 adrenoceptor beta 2, surface
ANOS1 anosmin 1
BACE2 beta-site APP-cleaving enzyme 2
BMP4 bone morphogenetic protein 4
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CPM carboxypeptidase M
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
ETV1 ets variant 1
FBLN1 fibulin 1
GRAMD3 GRAM domain containing 3
HP haptoglobin
IL1B interleukin 1, beta
INSIG1 insulin induced gene 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MYB v-myb avian myeloblastosis viral oncogene homolog
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPIF peptidylprolyl isomerase F
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RHOBTB3 Rho-related BTB domain containing 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SESN1 sestrin 1
SFTPC surfactant protein C
SOD2 superoxide dismutase 2, mitochondrial
SPAG4 sperm associated antigen 4
SPP1 secreted phosphoprotein 1
TFRC transferrin receptor
TSPAN7 tetraspanin 7
WNT5A wingless-type MMTV integration site family, member 5A