BRD-K85606544_neratinib_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K85606544_neratinib_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
CP ceruloplasmin (ferroxidase)
DEFB1 defensin, beta 1
ETV5 ets variant 5
FGB fibrinogen beta chain
GLS glutaminase
HMOX1 heme oxygenase 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KLF6 Kruppel-like factor 6
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
MT1X metallothionein 1X
NUPR1 nuclear protein, transcriptional regulator, 1
SATB1 SATB homeobox 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STEAP3 STEAP family member 3, metalloreductase
TFPI2 tissue factor pathway inhibitor 2
TPP1 tripeptidyl peptidase I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
CCL20 chemokine (C-C motif) ligand 20
CFH complement factor H
COL14A1 collagen, type XIV, alpha 1
COL4A5 collagen, type IV, alpha 5
CPM carboxypeptidase M
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
EPS8 epidermal growth factor receptor pathway substrate 8
EVL Enah/Vasp-like
FAM198B family with sequence similarity 198, member B
FBN1 fibrillin 1
FHL1 four and a half LIM domains 1
GSTM3 glutathione S-transferase mu 3 (brain)
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
MAPK13 mitogen-activated protein kinase 13
MREG melanoregulin
NR2F1 nuclear receptor subfamily 2, group F, member 1
PALLD palladin, cytoskeletal associated protein
PDLIM3 PDZ and LIM domain 3
PLAT plasminogen activator, tissue
PLN phospholamban
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB38 RAB38, member RAS oncogene family
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SDC2 syndecan 2
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TLR4 toll-like receptor 4
TSPAN4 tetraspanin 4
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)