BRD-K85606544_neratinib_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

283 genes differentially expressed following the BRD-K85606544_neratinib_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
AIF1 allograft inflammatory factor 1
AKR1C1 aldo-keto reductase family 1, member C1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA4 annexin A4
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BBS1 Bardet-Biedl syndrome 1
BCL6 B-cell CLL/lymphoma 6
BLVRB biliverdin reductase B
BTG1 B-cell translocation gene 1, anti-proliferative
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CD14 CD14 molecule
CD163 CD163 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CFD complement factor D (adipsin)
CLU clusterin
COL1A1 collagen, type I, alpha 1
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CTSD cathepsin D
CXCL2 chemokine (C-X-C motif) ligand 2
DEFB1 defensin, beta 1
DIAPH2 diaphanous-related formin 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNASE2 deoxyribonuclease II, lysosomal
EFHC1 EF-hand domain (C-terminal) containing 1
EFNA1 ephrin-A1
ENSA endosulfine alpha
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FAM13A family with sequence similarity 13, member A
FAM65B family with sequence similarity 65, member B
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
G6PD glucose-6-phosphate dehydrogenase
GAA glucosidase, alpha; acid
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GSE1 Gse1 coiled-coil protein
GUSBP11 glucuronidase, beta pseudogene 11
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT8 keratin 8, type II
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LIMK2 LIM domain kinase 2
LOX lysyl oxidase
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MT1X metallothionein 1X
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
NAV2 neuron navigator 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NPEPL1 aminopeptidase-like 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHGDH phosphoglycerate dehydrogenase
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2C phosphatidic acid phosphatase type 2C
PPL periplakin
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RAB25 RAB25, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBKS ribokinase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SH3YL1 SH3 and SYLF domain containing 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPTSSA serine palmitoyltransferase, small subunit A
STAB1 stabilin 1
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
TP53TG1 TP53 target 1 (non-protein coding)
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VSIG4 V-set and immunoglobulin domain containing 4
VWA5A von Willebrand factor A domain containing 5A
WFDC2 WAP four-disulfide core domain 2
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYR61 cysteine-rich, angiogenic inducer, 61
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
EFHD2 EF-hand domain family, member D2
EGR3 early growth response 3
EIF4E eukaryotic translation initiation factor 4E
ELOVL2 ELOVL fatty acid elongase 2
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL13RA2 interleukin 13 receptor, alpha 2
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NPY neuropeptide Y
NRG1 neuregulin 1
NUP85 nucleoporin 85kDa
NUP98 nucleoporin 98kDa
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLEK2 pleckstrin 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRSS3 protease, serine, 3
PTTG1 pituitary tumor-transforming 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RACGAP1 Rac GTPase activating protein 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SRSF6 serine/arginine-rich splicing factor 6
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TTK TTK protein kinase
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
VIM vimentin
VRK1 vaccinia related kinase 1
WSB2 WD repeat and SOCS box containing 2
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein