BRD-K85606544_neratinib_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K85606544_neratinib_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASPN asporin
BLVRB biliverdin reductase B
BST2 bone marrow stromal cell antigen 2
CD44 CD44 molecule (Indian blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DDIT4 DNA-damage-inducible transcript 4
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP1 dual specificity phosphatase 1
DUSP22 dual specificity phosphatase 22
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FLOT1 flotillin 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GATA3 GATA binding protein 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ISG20 interferon stimulated exonuclease gene 20kDa
KRAS Kirsten rat sarcoma viral oncogene homolog
MAN2B1 mannosidase, alpha, class 2B, member 1
MYO6 myosin VI
NCOA1 nuclear receptor coactivator 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHYH phytanoyl-CoA 2-hydroxylase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PYCR1 pyrroline-5-carboxylate reductase 1
RAP2A RAP2A, member of RAS oncogene family
REEP5 receptor accessory protein 5
SEPHS2 selenophosphate synthetase 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC22A18 solute carrier family 22, member 18
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STK26 serine/threonine protein kinase 26
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TRAPPC6A trafficking protein particle complex 6A
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
TWF2 twinfilin actin binding protein 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ARL4C ADP-ribosylation factor-like 4C
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPH aspartate beta-hydroxylase
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND2 cyclin D2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEMIP cell migration inducing protein, hyaluronan binding
CENPU centromere protein U
CNN3 calponin 3, acidic
CTGF connective tissue growth factor
CTPS1 CTP synthase 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUOX2 dual oxidase 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FEN1 flap structure-specific endonuclease 1
GBP1 guanylate binding protein 1, interferon-inducible
GTPBP8 GTP-binding protein 8 (putative)
IFI16 interferon, gamma-inducible protein 16
IGFBP7 insulin-like growth factor binding protein 7
IL13RA2 interleukin 13 receptor, alpha 2
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIG1 ligase I, DNA, ATP-dependent
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MMP7 matrix metallopeptidase 7
MYO10 myosin X
NET1 neuroepithelial cell transforming 1
NPY neuropeptide Y
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCG2 secretogranin II
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TLE4 transducin-like enhancer of split 4
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein